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Mild cognitive impairment and kidney disease: clinical aspects.
Nephrology Dialysis Transplantation,
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Microcirculatory dysfunction associates with neurovascular uncoupling in peri-ischemic brain regions after ischemic stroke. bioRxiv.
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, Gutiérrez-Jiménez, E., Guldbrandsen, H. Ø., Tang, J., Sandow, S. L.
, Boas, D. A. & Matchkov, V. (2023).
Neurovascular Uncoupling Is Linked to Microcirculatory Dysfunction in Regions Outside the Ischemic Core Following Ischemic Stroke.
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Cortical Microvascular Pulsatility in the Aging Mouse Brain and the Confounding Effects of Anesthesia.
Advanced Science,
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The capillary dysfunction hypothesis of Alzheimer's disease.
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The role of the microcirculation in delayed cerebral ischemia and chronic degenerative changes after subarachnoid hemorrhage.
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Capillary dysfunction: Its detection and causative role in dementias and stroke.
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Head holder and cranial window design for sequential magnetic resonance imaging and optical imaging in awake mice.
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Basic Science and Pathogenesis.
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Martínez Héctor, R., Caro-Osorio, E.
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Amiotrofia monomiélica.
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Martínez, H. R., Molina-Lopez, J. F., González-Garza, M. T., Moreno-Cuevas, J. E., Caro-Osorio, E., Gil-Valadez, A.
, Gutierrez-Jimenez, E., Zazueta-Fierro, O. E., Meza, J. A., Couret-Alcaraz, P. & Hernandez-Torre, M. (2012).
Stem cell transplantation in amyotrophic lateral sclerosis patients: methodological approach, safety, and feasibility.
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, Gutierrez-Jimenez, E. & Segura, J. J. (2009).
Stem-cell transplantation into the frontal motor cortex in amyotrophic lateral sclerosis patients.
Cytotherapy,
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, Gutierrez-Jimenez, E., Rapoport, D. M. & Osorio, R. S. (2024).
Obstructive Sleep Apnea, Platelet Aggregation, and Cardiovascular Risk.
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, Gutierrez-Jimenez, E., Fillmore, N. R., Gonzalez, M., Figueredo, L., Gaggi, N. L., Plaska, C. R., Pomara, N., Blessing, E., Betensky, R., Rusinek, H., Zetterberg, H., Blennow, K. ... Ramos-Cejudo, J. (2024).
The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people.
Immunity & ageing ,
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, Nielsen, R., Frische, S., Trepiccione, F., Hafez, G., Altunkaynak, H. O., Endlich, N., Unwin, R., Capasso, G., Pesic, V. ... CONNECT Consortium (2024).
Animal models to study cognitive impairment of chronic kidney disease.
American journal of physiology. Renal physiology,
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, Mouridsen, K., Jespersen, S. N., Lee, J.
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Effect of electrical forepaw stimulation on capillary transit-time heterogeneity (CTH).
Journal of Cerebral Blood Flow and Metabolism,
36(12), 2072-2086.
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Gutiérrez-Jiménez, E., Angleys, H., Rasmussen, P. M., Mikkelsen, I. K., Mouridsen, K. & Østergaard, L. (2018).
The effects of hypercapnia on cortical capillary transit time heterogeneity (CTH) in anesthetized mice.
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The effect of carbonic anhydrase inhibitors in brain microcirculation of the Tg-SwDI model of Alzheimer's disease.
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Carbonic anhydrase inhibitors prevent presymptomatic capillary flow disturbances in a model of cerebral amyloidosis.
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Disturbances in the control of capillary flow in an aged APP(swe)/PS1 Delta E9 model of Alzheimer's disease.
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, Lassen, T. R., Jørgensen, M., Bæk, R.
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The Role of Plasma Extracellular Vesicles in Remote Ischemic Conditioning and Exercise-Induced Ischemic Tolerance.
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Fruekilde, S. K., Bailey, C. J., Lambertsen, K. L., Clausen, B. H.
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, Drasbek, K. R. & Gutiérrez-Jiménez, E. (2022).
Disturbed microcirculation and hyperaemic response in a murine model of systemic inflammation.
Journal of Cerebral Blood Flow and Metabolism,
42(12), 2303-2317.
https://doi.org/10.1177/0271678X221112278
Farahani, E., Reinert, L. S., Narita, R., Serrero, M. C., Skouboe, M. K., van der Horst, D., Assil, S., Zhang, B., Iversen, M. B., Gutierrez, E., Hazrati, H., Johannsen, M., Olagnier, D., Kunze, R.
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& Paludan, S. R. (2024).
The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation.
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Dudele, A., Gutierrez, E., Iversen, N. K., Frische, S., Staehelin-Jensen, T. & Østergaard, L. (2017).
Capillary dysfunction in the development of diabetic peripheral neuropathy in animal models. 276-276. Abstract from 2017 PNS (Peripheral Nerve Society) Annual Meeting , Barcelona, Spain.
https://doi.org/10.1111/jns.12225
Carlsen, J., Fossati, S.
, Østergaard, L., Gutiérrez-Jiménez, E. & Palmfeldt, J. (2025).
Cerebral proteome adaptations to amyloid angiopathy are prevented by carbonic anhydrase inhibitors.
Alzheimer's and Dementia,
21(4), Article e70122.
https://doi.org/10.1002/alz.70122
Canepa, E., Parodi-Rullan, R., Vazquez-Torres, R., Gamallo-Lana, B., Guzman-Hernandez, R., Lemon, N. L., Angiulli, F., Debure, L., Ilies, M. A.
, Østergaard, L., Wisniewski, T.
, Gutiérrez-Jiménez, E., Mar, A. C. & Fossati, S. (2023).
FDA-approved carbonic anhydrase inhibitors reduce amyloid β pathology and improve cognition, by ameliorating cerebrovascular health and glial fitness.
Alzheimer's & Dementia,
19(11), 5048-5073.
https://doi.org/10.1002/alz.13063Bordoni, L., Jiménez, E. G., Nielsen, S.
, Østergaard, L. & Frische, S. (2020).
A new experimental mouse model of water intoxication with sustained increased intracranial pressure and mild hyponatremia without side effects of antidiuretics.
Experimental animals,
69(1), 92-103.
https://doi.org/10.1538/expanim.19-0040
Bordoni, L., Li, B., Kura, S.
, Boas, D. A., Sakadžić, S.
, Østergaard, L., Frische, S. & Gutiérrez-Jiménez, E. (2021).
Quantification of Capillary Perfusion in an Animal Model of Acute Intracranial Hypertension.
Journal of Neurotrauma,
38(4), 446-454.
https://doi.org/10.1089/neu.2019.6901
Bordoni, L., Thoren, A. E.
, Gutiérrez-Jiménez, E., Åbjørsbråten, K. S., Bjørnstad, D. M., Tang, W.
, Stern, M., Østergaard, L., Nagelhus, E. A.
, Frische, S., Ottersen, O. P. & Enger, R. (2023).
Deletion of aquaporin-4 improves capillary blood flow distribution in brain edema.
Glia,
71(11), 2559-2572.
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