Vibeke Bay is defending her Master in Molecular Medicine 
Wednesday 18 February 2015 at 13.00 in the Pathology Auditorium, AUH.

Supervisor: Kim Ryun Drasbek
Censor: Torben Moos

Remote ischemic conditioning
Evaluating the protective effect in a stroke model & identifying the blood borne factor that conveys ischemic protection

Conditioning, i.e. controlled short, repeated ischemic episodes, is found to decrease infarct size in both stroke and acute myocardial infarct (AMI). This interesting effect could be mediated by microRNAs (miRNAs) by changing expression patterns in target cells and thereby altering them to withstand ischemia.

The presentation is divided into two parts. Firstly, I will present an experiment used to study the effect of remote per-conditioning in a middle cerebral artery occlusion (MCAO) rat model by analyzing the infarct size by MRI. Secondly, I will present an experiment in which we extracted blood from human subjects before and after conditioning, and plasma and exosomes fractions were evaluated by next generation sequencing to reveal differences in miRNA expression.

If the mechanism of conditioning can be determined, this would facilitate the development of treatments against not only stroke and AMI, but also other ischemic diseases.

ALL ARE WELCOME.