Phil Nova B.S. (Hons)
Yadong Huang lab, Gladstone Institute for Neurological Disease
University of California San Francisco (UCSF).

Tentative Title:

APOE4 and Alzheimer’s Disease: Mechanistic and Therapeutic Aspects

The Yadong Huang lab at UCSF explores the genetic Alzheimer's risk factor ApoE4, and how this risk factor promotes Alzheimer's disease in both ABeta-dependent and -independent mechanisms. In particular, they use mouse models to understand how ApoE4 causes a deficit in hippocampal inhibition, which leads to altered network states, behavioral deficits, and a variety of cellular and molecular dysfunctions. In recent years the Huang lab has also explored strategies to restore inhibitory / excitatory balance in Alzheimer's, using genetic, pharmacological, and stem-cell based therapies.

Phil Nova is making a private visit to Aarhus and kindly offered to provide us with highlights of the past few years of research in the Huang Lab and their current and future directions.

ALL ARE WELCOME