Neurons are extremely vulnerable to starvation. Therefore, a well-functioning vascular system that provides nutrients and oxygen, and removes waste, is crucial for maintaining a healthy cerebral environment.

This defence will describe the process of designing an experimental setup and analysis protocol, which allowed for a longitudinal investigation of the cerebral vascular system in mice. Overall, we revealed how a severe systemic inflammation caused a disturbance in the normal flow of blood within the capillary network. These findings are discussed as a potential danger to neuronal health, since demands of oxygen and nutrition may not be met by the vascular system during inflammation.

The potential of the developed protocols extends beyond inflammation to many questions related to the health and resilience of the cerebrovascular system.

The defence is public and takes place on:

Wednesday 18 August 2021 at 4:00 pm
in Samfundsmedicinsk auditorium, Aarhus University, Bartholins Allé, Building 1262.

The title of the project is:
”Longitudinal imaging of cerebrovascular dynamics in awake mice using optical techniques”.

Assessment committee:

• Professor Christian Aalkjær
  Department of Biomedicin, Aarhus Universitet
• Associate Professor Andy Shih
  Center for Developmental Biology and Regenerative Medicin, Seattle Children's Research Institute & University of Washington
• Professor, Senior Consultant Kirsten Møller
  Department of Neurointensive Care and Neuroanaesthesiology, Neuroscience Centre, University Hospital Rigshospitalet & Department of Clinical Medicin, Faculty of Health Sciences, University of Copenhagen

ALL ARE WELCOME

After the defense there will be a small reception at CFIN:

Building 1710
Universitetsbyen 3, 8000 Aarhus C.

Contact

For more information, please contact:
PhD student Signe Kirk Fruekilde
email: skf@cfin.au.dk
Phone +45 28253176