Functional Hemodynamics

The functional hemodynamics group examines the role of the microcirculation in health and disease.

Our research includes 

  • The development of theoretical models, which take the distribution of blood across the capillary bed into account when calculating the net extraction of oxygen, glucose, and other nutrients as blood passes through tissue
  • The development, validation and implementation of methods to allow direct observation of capillary blood flows in tissue, as well as blood and tissue levels of oxygen and other substances, in experimental models
  • The development of computational tools to infer key physiological indices from information-rich direct microvascular recordings  
  • The development, implementation and validation of methods to infer microvascular flow distributions noninvasively in humans, using contrast-enhanced scanning techniques such as magnetic resonance imaging, computerized tomography, and ultrasound
  • Studies of microvascular function in the central and peripheral nervous system in health and disease

We collaborate closely with the Neurophysics Group to develop theoretical models, with the Neuroinformatics Group and with the Two Photon Microscopy and MRI facilities to develop new methods, and with the Applied Imaging and Modelling group regarding data analysis and comparison to other disease biomarkers.

Coordinator: Leif Østergaard

Leif Østergaard