CFIN postdoc Nick Yao Larsen wins Outstanding Paper Award
CFIN researcher (postdoc in Diego Vidaurre's Analysis Group), Nick Yao Larsen has been awarded the "Outstanding Paper Award in memory of Hans Jørgen G. Gundersen" in 2021 for his article on "Cellular 3D-reconstruction and analysis in the human cerebral cortex using automatic serial sections". The article is published in Communications Biology.
Nick Y Larsen, Xixia Li, Xueke Tan, Gang Ji, Jing Lin, Grazyna Rajkowska, Jesper Møller, Ninna Vihrs, Jon Sporring, Fei Sun, Jens R Nyengaard
Cellular 3D-reconstruction and analysis in the human cerebral cortex using automatic serial sections.
Techniques involving three-dimensional (3D) tissue structure reconstruction and analysis provide a better understanding of changes in molecules and function. We have developed AutoCUTS-LM, an automated system that allows the latest advances in 3D tissue reconstruction and cellular analysis developments using light microscopy on various tissues, including archived tissue. The workflow in this paper involved advanced tissue sampling methods of the human cerebral cortex, an automated serial section collection system, digital tissue library, cell detection using convolution neural network, 3D cell reconstruction, and advanced analysis. Our results demonstrated the detailed structure of pyramidal cells (number, volume, diameter, sphericity and orientation) and their 3D spatial organization are arranged in a columnar structure. The pipeline of these combined techniques provides a detailed analysis of tissues and cells in biology and pathology.
For the Outstanding Paper Award in memory of Hans Jørgen G Gundersen, Nick Yao Larsen is awarded 2000 EUR and the opportunity to present his work in the 16th International Conference for Stereology and Image Analysis that will take place in Xi'an, China on October 27-30, 2023.
Read more about the Outstanding Paper Award in memory of Hans Jørgen G Gundersen at: