The PhD thesis focuses on investigating the use of phage display of recombinant antibodies for the discovery of novel pericyte biomarkers. Pericytes are a vital component of microvessels with important functions in vascular development, stabilization, and remodelling. Since reduced capillary pericyte-coverage and pericyte-disfunction play a role in various neurodegenerative disorders, the development of relevant pericyte biomarkers should help understand the contribution of pericytes to these and other pathological conditions.

The work was divided into two principal parts: the generation of a domain antibody library for phage display and the development of novel selection method to target antigens present on the pericyte cell membrane. The project has contributed to the generation of four individual manuscripts of which the PhD student is the first-author on two.

The defense is public and will take place:

DATE: Monday 23 January 2017
TIME: 13.00
PLACE: Biochemistry 6, Aarhus University (building 1170, room 347)

ALL ARE WELCOME 

Assessment Committee:

• Professor Michael Robert Horsman – chairman and moderator of the defence
  Institute of Clinical Medicine, Department of Experimental Clinical Oncology, Aarhus University

• Group Leader, Research Director 1st class Franck Perez
  Institute Curie, Paris, France

• Professor Torben Moos 
  Department of Health Science and Technology, Aalborg University

• Associate Professor Kim Ryun Drasbek – main supervisor and non-voting member
  CFIN, Department of Clinical Medicine, Aarhus University