Wu, O., Østergaard, L., Koroshetz, W. J., Schwamm, L. H., ODonnell, J., Schaefer, P. W., Rosen, B. R., Weisskoff, R. M. & Sorensen, A. G. (2003).
Tracer arrival timing insensitive technique for estimating flow in MR perfusion-weighted imaging using singular value decomposition with a block-circulant deconvolution matrix.
Magnetic Resonance in Medicine,
50(1), 164-174.
https://doi.org/10.1002/mrm.10522
Perkiö, J., Aronen, H. J., Kangasmäki, A., Liu, Y., Karonen, J., Savolainen, S.
& Østergaard, L. (2002).
Evaluation of four postprocessing methods for determination of cerebral blood volume and mean transit time by dynamic susceptibility contrast imaging.
Magnetic Resonance in Medicine,
47(5), 973-81.
https://doi.org/10.1002/mrm.10126
Simonsen, C. Z., Røhl, L., Vestergaard-Poulsen, P., Gyldensted, C., Andersen, G. & Østergaard, L. (2002).
Final infarct size after acute stroke: prediction with flow heterogeneity.
Radiology,
225(1), 269-75.
https://doi.org/10.1148/radiol.2251011249
Yamada, K., Gonzalez, R. G.
, Østergaard, L., Komili, S., Weisskoff, R. M., Rosen, B. R., Koroshetz, W. J., Nishimura, T. & Sorensen, A. G. (2002).
Iron-induced susceptibility effect at the globus pallidus causes underestimation of flow and volume on dynamic susceptibility contrast-enhanced MR perfusion images.
American Journal of Neuroradiology,
23(6), 1022-9.
Yamada, K.
, Wu, O., Gonzalez, R. G., Bakker, D.
, Østergaard, L., Copen, W. A., Weisskoff, R. M., Rosen, B. R., Yagi, K., Nishimura, T. & Sorensen, A. G. (2002).
Magnetic resonance perfusion-weighted imaging of acute cerebral infarction: effect of the calculation methods and underlying vasculopathy.
Stroke; a journal of cerebral circulation,
33(1), 87-94.
https://doi.org/10.1161/hs0102.101893
Aronen, H. J., Perkiö, J., Karonen, J. O., Vanninen, R. L.
, Østergaard, L., Liu, Y., Könönen, M., Vanninen, E. J., Soimakallio, S. & Kuikka, J. T. (2002).
Perfusion-weighted MRI in human acute ischemic stroke: a comparison with the progression of the infarct on diffusion-weighted images.
Academic Radiology,
9(Suppl 1), S160-4.
https://doi.org/10.1016/S1076-6332(03)80427-0
Røhl, L., Sakoh, M.
, Simonsen, C. Z., Vestergaard-Poulsen, P., Sangill, R., Sørensen, J. C. H., Bjarkam, C., Gyldensted, C. & Østergaard, L. (2002).
Time evolution of cerebral perfusion and apparent diffusion coefficient measured by magnetic resonance imaging in a porcine stroke model.
Journal of Magnetic Resonance Imaging,
15(2), 123-9.
https://doi.org/10.1002/jmri.10068
Smith, D. F., Hansen, S. B., Østergaard, L., Gee, A. D.
, Danielsen, E., Ishizu, K.
, Bender, D., Poulsen, P. H.
& Gjedde, A. (2001).
[14C]Serotonin uptake and [O-methyl-11C]venlafaxine kinetics in porcine brain. Nuclear Medicine and Biology,
28(6), 633-8.
https://doi.org/10.1016/S0969-8051(01)00230-X
Røhl, L., Geday, J., Østergaard, L., Simonsen, C. Z., Vestergaard-Poulsen, P., Andersen, G., Le Bihan, D.
& Gyldensted, C. (2001).
Correlation between diffusion- and perfusion-weighted MRI and neurological deficit measured by the Scandinavian Stroke Scale and Barthel Index in hyperacute subcortical stroke (< or = 6 hours).
Cerebrovascular Diseases,
12(3), 203-213.
https://doi.org/10.1159/000047705
Karonen, J. O.
, Østergaard, L., Vainio, P., Partanen, K., Vanninen, R., Vanninen, E., Korhonen, K., Haapamäki, S., Liu, Y., Roivainen, R., Onatsu, J., Nuutinen, J., Könönen, M., Sivenius, J., Kuikka, J. & Aronen, H. J. (2001).
Diffusion and perfusion MR imaging in acute ischemic stroke: a comparison to SPECT.
Computer Methods and Programs in Biomedicine,
66(1), 125-8.
https://doi.org/10.1016/S0169-2607(01)00146-8
Danielsen, E. H., Smith, D. F., Andersen, F., Gee, A. D.
, Bender, D., Hansen, S. B., Hermansen, F., Østergaard, L., Cumming, P. & Gjedde, A. (2001).
FDOPA metabolism in the adult porcine brain: influence of tracer circulation time and VOI selection on estimates of striatal DOPA decarboxylation. Journal of Neuroscience Methods,
111(2), 157-68.
https://doi.org/10.1016/S0165-0270(01)00453-8
Simonsen, C. Z., Røhl, L., Østergaard, L., Vestergaard-Poulsen, P., Andersen, G. & Gyldensted, C. (2001).
MR-scanning ved akut apopleksi.
Ugeskrift for Læger,
163(17), 2368-72.
Wu, O., Koroshetz, W. J.
, Østergaard, L., Buonanno, F. S., Copen, W. A., Gonzalez, R. G., Rordorf, G., Rosen, B. R., Schwamm, L. H., Weisskoff, R. M. & Sorensen, A. G. (2001).
Predicting tissue outcome in acute human cerebral ischemia using combined diffusion- and perfusion-weighted MR imaging.
Stroke; a journal of cerebral circulation,
32(4), 933-42.
https://doi.org/10.1161/01.STR.32.4.933
Sakoh, M.
, Østergaard, L., Gjedde, A., Røhl, L., Vestergaard-Poulsen, P., Smith, D. F., Le Bihan, D., Sakaki, S.
& Gyldensted, C. (2001).
Prediction of tissue survival after middle cerebral artery occlusion based on changes in the apparent diffusion of water. Journal of Neurosurgery,
95(3), 450-8.
Lin, W., Celik, A., Derdeyn, C., An, H., Lee, Y., Videen, T.
, Østergaard, L. & Powers, W. J. (2001).
Quantitative measurements of cerebral blood flow in patients with unilateral carotid artery occlusion: a PET and MR study.
Journal of Magnetic Resonance Imaging,
14(6), 659-67.
https://doi.org/10.1002/jmri.10021
Røhl, L., Østergaard, L., Simonsen, C. Z., Vestergaard-Poulsen, P., Andersen, G., Sakoh, M., Le Bihan, D.
& Gyldensted, C. (2001).
Viability thresholds of ischemic penumbra of hyperacute stroke defined by perfusion-weighted MRI and apparent diffusion coefficient.
Stroke,
32, 1140-1146.
https://doi.org/10.1161/01.STR.32.5.1140
Wirestam, R., Andersson, L.
, Østergaard, L., Bolling, M., Aunola, J., Lindgren, A., Geijer, B., Holtås, S. & Ståhlberg, F. (2000).
Assessment of regional cerebral blood flow by dynamic susceptibility contrast MRI using different deconvolution techniques.
Magnetic Resonance in Medicine,
43(5), 691-700.
https://doi.org/10.1002/(SICI)1522-2594(200005)43:5<691::AID-MRM11>3.0.CO;2-B
Sakoh, M.
, Røhl, L., Gyldensted, C., Gjedde, A. & Østergaard, L. (2000).
Cerebral blood flow and blood volume measured by magnetic resonance imaging bolus tracking after acute stroke in pigs: comparison with [(15)O]H(2)O positron emission tomography. Stroke,
31(8), 1958-64.
https://doi.org/10.1161/01.STR.31.8.1958
Bergholt, B., Østergaard, L., Oettingen, G. V., Johannsen, P., Poulsen, P. H., Bundgaard, H., Asboe, H.
, Cold, G., Gjedde, A., Gyldensted, C. & Astrup, J. (2000).
Cerebral blood flow in volunteers measured by PET and Xe CT/CBF: A comparison.
Keio Journal of Medicine,
49(Suppl 1), 55-57.
https://doi.org/10.2302/kjm.49.supplement1_A51
Chabriat, H., Pappata, S.
, Østergaard, L., Clark, C. A., Pachot-Clouard, M., Vahedi, K., Jobert, A., Le Bihan, D. & Bousser, M. G. (2000).
Cerebral hemodynamics in CADASIL before and after acetazolamide challenge assessed with MRI bolus tracking.
Stroke,
31(8), 1904-12.
https://doi.org/10.1161/01.STR.31.8.1904
Liu, Y., Karonen, J. O., Vanninen, R. L.
, Østergaard, L., Roivainen, R., Nuutinen, J., Perkiö, J. P., Könönen, M., Hämäläinen, A., Vanninen, E. J., Soimakallio, S., Kuikka, J. T. & Aronen, H. J. (2000).
Cerebral Hemodynamics in Human Acute Ischemic Stroke: A Study with Diffusion- and Perfusion-Weighted Magnetic Resonance Imaging and SPECT.
Journal of Cerebral Blood Flow and Metabolism,
20(6), 910-920.
https://doi.org/10.1097/00004647-200006000-00003
Østergaard, L., Sorensen, A. G., Chesler, D. A., Weisskoff, R. M., Koroshetz, W. J.
, Wu, O., Gyldensted, C. & Rosen, B. R. (2000).
Combined diffusion-weighted and perfusion-weighted flow heterogeneity magnetic resonance imaging in acute stroke.
Stroke,
31(5), 1097-103.
https://doi.org/10.1161/01.STR.31.5.1097
Karonen, J. O., Liu, Y., Vanninen, R. L.
, Østergaard, L., Kaarina Partanen, P. L., Vainio, P. A., Vanninen, E. J., Nuutinen, J., Roivainen, R., Soimakallio, S., Kuikka, J. T. & Aronen, H. J. (2000).
Combined perfusion- and diffusion-weighted MR imaging in acute ischemic stroke during the 1st week: a longitudinal study.
Radiology,
217(3), 886-94.
https://doi.org/10.1148/radiology.217.3.r00dc02886
Østergaard, L., Vestergaard-Poulsen, P., Bentzen, L. N., Horsman, M. R.
, Overgaard, J., Bjørnerud, A., Briley-Sæbø, K.
& Gyldensted, C. (2000).
Comparison of Gd-DTPA BMA and NC100150 Enhancement Patterns in C3H Mammary Carcinoma Bearing Mice. In
Proc. Intl. Sot. Mag. Reson. Med. 8 (pp. 2019-2019)
Simonsen, C. Z., Østergaard, L., Smith, D. F., Vestergaard-Poulsen, P. & Gyldensted, C. (2000).
Comparison of gradient- and spin-echo imaging: CBF, CBV, and MTT measurements by bolus tracking.
Journal of Magnetic Resonance Imaging,
12(3), 411-6.
https://doi.org/10.1002/1522-2586(200009)12:3<411::AID-JMRI6>3.0.CO;2-5
Perkiö, J., Aronen, H. J., Karonen, J., Liu, Y., Savolainen, S.
& Østergaard, L. (2000).
Determination of Cerebral Blood Volume and Mean Transit Time by Dynamic Contrast Enhanced MR Imaging in Patients with Acute Stroke: A Comparison of Four Post Processing Methods. In
Proc. Intl. Sot. Mag. Reson. Med. 8 (pp. 527-527)
Perkiö, J., Soinne, L.
, Østergaard, L., Tatlisumak, T., Kangsmäki, A., Helenius, J., Martinkauppi, S., Salonen, O., Savolainen, S., Kaste, M. & Aronen, H. J. (2000).
Dynamic MR Bolus Tracking in Hyperacute Stroke: Comparison with Diffusion Weighted MR Imaging. In
Proc. Intl. Soc. Mag. Reson. Med. 8 (pp. 450-450)
Benner, T., Tombach, B., Synnott, J. P., Schuierer, G., Reimer, P., Geens, V.
, Østergaard, L. & Sorensen, A. G. (2000).
Human Cerebral Blood Flow Maps Improve with Higher Concentration of Contrast Agent. In
ISMRM 8th Scientific Meeting & Exhibition - Proceedings
Bentzen, L. N., Vestergaard-Poulsen, P., Horsman, M. R.
, Overgaard, J., Bjørnerud, A., Briley-Sæbø, K.
, Gyldensted, C. & Østergaard, L. (2000).
NC100150 Enhanced Imaging Offers the Possibility to Monitor Pharmacological Modification of Tumor Blood Flow and Blood Volume in Experimental Tumors in Mice. In
ISMRM 8th Scientific Meeting & Exhibition - Proceedings Article 2030
von Oettingen, G., Bergholt, B., Rasmussen, M., Østergaard, L. & Astrup, J. (2000).
Pulmonary function affects the quantification of rCBF by non-invasive xenon methods.
Journal of Neuroscience Methods,
95(2), 159-69.
https://doi.org/10.1016/S0165-0270(99)00179-X
Li, T.-Q., Chen, Z. G.
, Østergaard, L., Hindmarsh, T. & Moseley, M. E. (2000).
Quantification of Cerebral Blood Flow by Using Bolus Tracking and Artery Spin Tagging Methods.
Magnetic Resonance Imaging,
18(5), 503-512.
https://doi.org/10.1016/S0730-725X(00)00137-5
Lythgoe, D. J.
, Østergaard, L., William, S. C., Cluckie, A., Buxton-Thomas, M., Simmons, A. & Markus, H. S. (2000).
Quantitative perfusion imaging in carotid artery stenosis using dynamic susceptibility contrast-enhanced magnetic resonance imaging.
Magnetic Resonance Imaging,
18(1), 1-11.
https://doi.org/10.1016/S0730-725X(99)00112-5
Markus, H. S., Lythgoe, D.
, Østergaard, L., O'Sullivan, M. & Williams, S. C. R. (2000).
Reduced cerebral blood flow in white matter in ischaemic leukoaraiosis demonstrated using quantitative exogenous contrast based perfusion MRI.
Journal of Neurology, Neurosurgery & Psychiatry,
69(1), 48-53.
https://doi.org/10.1136/jnnp.69.1.48
Wirestam, R., Ryding, E., Lindgren, A., Geijer, B.
, Østergaard, L., Andersson, L., Holtås, S. & Ståhlberg, F. (2000).
Regional cerebral blood flow distributions in normal volunteers: dynamic susceptibility contrast MRI compared with 99mTc-HMPAO SPECT.
Journal of Computer Assisted Tomography,
24(4), 526-30.
Sakoh, M.
, Østergaard, L., Røhl, L., Smith, D. F., Simonsen, C. Z., Sørensen, J. C. H., Vestergaard-Poulsen, P., Gyldensted, C., Sakaki, S.
& Gjedde, A. (2000).
Relationship between residual cerebral blood flow and oxygen metabolism as predictive of ischemic tissue viability: sequential multitracer positron emission tomography scanning of middle cerebral artery occlusion during the critical first 6 hours after stroke in pigs. Journal of Neurosurgery,
93(4), 647-57.
Danielsen, E. H., Cumming, P., Andersen, F.
, Bender, D., Brevig, T., Falborg, L., Gee, A., Gillings, N. M., Hansen, S. B., Hermansen, F., Johansen, J., Johansen, T. E., Dahl-Jørgensen, A., Jørgensen, H. A., Meyer, M.
, Munk, O. L., Pedersen, E. B., Poulsen, P. H., Rodell, A. B.
... Møller, A. (2000).
The DaNeX Study of Embryonic Mesencephalic Dopaminergic Tissue Grafted to a Minipig model of Parkinson's disease: Preliminary Findings of Effect of MPTP-Poisoning on Striatal Dopaminergic Markers.
Cell Transplantation,
9(2), 247-259.
https://doi.org/10.1177/096368970000900210
Oettingen, G. V., Bergholt, B., Østergaard, L., Rasmussen, M., Gyldensted, C. & Astrup, J. (2000).
The influence of the input function on quantitative rCBF by the Xe/CT method.
Keio Journal of Medicine,
49(Suppl 1), 11-15.
Røhl, L., Østergaard, L., Simonsen, C. Z., Vestergaard-Poulsen, P., Andersen, G., Le Bihan, D.
& Gyldensted, C. (2000).
Viability Thresholds of the Penumbra of Acute Human Ischemic Stroke Defined from rCBF and rCBV.
Proc ISMRM, 452-452.
von Oettingen, G., Bergholt, B., Østergaard, L., Jensen, L. C., Gyldensted, C. & Astrup, J. (2000).
Xenon CT cerebral blood flow in patients with head injury: influence of pulmonary trauma on the input function.
Neuroradiology,
42(3), 168-73.
Zelaya, F., Flood, N., Chalk, J. B., Wang, D., Doddrell, D. M., Strugnell, W., Benson, M.
, Østergaard, L., Semple, J. & Eagle, S. (1999).
An evaluation of the time dependence of the anisotropy of the water diffusion tensor in acute human ischemia.
Magnetic Resonance Imaging,
17(3), 331-48.
https://doi.org/10.1016/S0730-725X(98)00192-1
Simonsen, C. Z., Østergaard, L., Vestergaard-Poulsen, P., Røhl, L., Bjørnerud, A.
& Gyldensted, C. (1999).
CBF and CBV measurements by USPIO bolus tracking: reproducibility and comparison with Gd-based values.
Journal of Magnetic Resonance Imaging,
9(2), 342-7.
https://doi.org/10.1002/(SICI)1522-2586(199902)9:2<342::AID-JMRI29>3.0.CO;2-B
Karonen, J. O., Vanninen, R. L., Liu, Y.
, Østergaard, L., Kuikka, J. T., Nuutinen, J., Vanninen, E. J., Partanen, P. L., Vainio, P. A., Korhonen, K., Perkiö, J., Roivainen, R., Sivenius, J. & Aronen, H. J. (1999).
Combined diffusion and perfusion MRI with correlation to single-photon emission CT in acute ischemic stroke. Ischemic penumbra predicts infarct growth.
Stroke,
30(8), 1583-90.
https://doi.org/10.1161/01.STR.30.8.1583
Østergaard, L., Hochberg, F. H., Rabinov, J. D., Sorensen, A. G., Lev, M., Kim, L., Weisskoff, R. M., Gonzalez, R. G.
, Gyldensted, C. & Rosen, B. R. (1999).
Early changes measured by magnetic resonance imaging in cerebral blood flow, blood volume, and blood-brain barrier permeability following dexamethasone treatment in patients with brain tumors.
Journal of Neurosurgery,
90(2), 300-5.
Sorensen, A. G., Copen, W. A.
, Østergaard, L., Buonanno, F. S., Gonzalez, R. G., Rordorf, G., Rosen, B. R., Schwamm, L. H., Weisskoff, R. M. & Koroshetz, W. J. (1999).
Hyperacute stroke: simultaneous measurement of relative cerebral blood volume, relative cerebral blood flow, and mean tissue transit time.
Radiology,
210(2), 519-27.
https://doi.org/10.1148/radiology.210.2.r99fe06519
Østergaard, L., Chesler, D. A., Weisskoff, R. M., Sorensen, A. G. & Rosen, B. R. (1999).
Modeling cerebral blood flow and flow heterogeneity from magnetic resonance residue data.
Journal of Cerebral Blood Flow and Metabolism,
19(6), 690-9.
https://doi.org/10.1097/00004647-199906000-00013
Røhl, L., Østergaard, L., Simonsen, C. Z., Vestergaard-Poulsen, P., Sørensen, L., Bjørnerud, A., Saebø, K. B.
& Gyldensted, C. (1999).
NC100150-enhanced 3D-SPGR MR angiography of the common carotid artery in a pig vascular stenosis model: Quantification of stenosis and dose optimization.
Acta Radiologica,
40(3), 282-90.
https://doi.org/10.3109/02841859909175555
Sanchez del Rio, M., Bakker, D.
, Wu, O., Agosti, R., Mitsikostas, D. D.
, Østergaard, L., Wells, W. A., Rosen, B. R., Sorensen, G., Moskowitz, M. A. & Cutrer, F. M. (1999).
Perfusion weighted imaging during migraine: spontaneous visual aura and headache.
Cephalalgia,
19(8), 701-7.
Østergaard, L., Smith, D. F., Vestergaard-Poulsen, P., Hansen, S. B., Gee, A. D.
, Gjedde, A. & Gyldensted, C. (1998).
Absolute cerebral blood flow and blood volume measured by magnetic resonance imaging bolus tracking: comparison with positron emission tomography values.
Journal of Cerebral Blood Flow and Metabolism,
18(4), 425-32.
https://doi.org/10.1097/00004647-199804000-00011
Østergaard, L., Johannsen, P., Høst-Poulsen, P.
, Vestergaard-Poulsen, P., Asboe, H., Gee, A. D.
, Hansen, S. B., Cold, G. E., Gjedde, A. & Gyldensted, C. (1998).
Cerebral blood flow measurements by magnetic resonance imaging bolus tracking: comparison with [(15)O]H2O positron emission tomography in humans.
Journal of Cerebral Blood Flow and Metabolism,
18(9), 935-40.
https://doi.org/10.1097/00004647-199809000-00002
Cutrer, F. M., Sorensen, A. G., Weisskoff, R. M.
, Østergaard, L., Sanchez del Rio, M., Lee, E. J., Rosen, B. R. & Moskowitz, M. A. (1998).
Perfusion-weighted imaging defects during spontaneous migrainous aura.
Annals of Neurology,
43(1), 25-31.
https://doi.org/10.1002/ana.410430108
Sorensen, A. G., Tievsky, A. L.
, Østergaard, L., Weisskoff, R. M. & Rosen, B. R. (1997).
Contrast agents in functional MR imaging.
Journal of Magnetic Resonance Imaging,
7(1), 47-55.
Poulsen, P. H.
, Smith, D. F., Østergaard, L., Danielsen, E. H., Gee, A.
, Hansen, S. B., Astrup, J.
& Gjedde, A. (1997).
In vivo estimation of cerebral blood flow, oxygen consumption and glucose metabolism in the pig by [15O]water injection, [15O]oxygen inhalation and dual injections of [18F]fluorodeoxyglucose.
Journal of Neuroscience Methods,
77(2), 199-209.
https://doi.org/10.1016/S0165-0270(97)00127-1
Østergaard, L., Sorensen, A. G., Kwong, K. K., Weisskoff, R. M.
, Gyldensted, C. & Rosen, B. R. (1996).
High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part II: Experimental comparison and preliminary results.
Magnetic Resonance in Medicine,
36(5), 726-36.
https://doi.org/10.1002/mrm.1910360511
Østergaard, L., Weisskoff, R. M., Chesler, D. A.
, Gyldensted, C. & Rosen, B. R. (1996).
High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part I: Mathematical approach and statistical analysis.
Magnetic Resonance in Medicine,
36(5), 715-25.
https://doi.org/10.1002/mrm.1910360510
Kwong, K. K., Chesler, D. A., Weisskoff, R. M., Donahue, K. M., Davis, T. L.
, Østergaard, L., Campbell, T. A. & Rosen, B. R. (1995).
MR perfusion studies with T1-weighted echo planar imaging.
Magnetic Resonance in Medicine,
34(6), 878-87.
https://doi.org/Harvard-MIT Division of Health Sciences & Technology