Publications

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Stokholm, K., Thomsen, M. B., Phan, J. A., Møller, L. K., Bay-Richter, C., Christiansen, S. H., Woldbye, D. P. D., Romero-Ramos, M. & Landau, A. M. (2021). α-Synuclein Overexpression Increases Dopamine D2/3 Receptor Binding and Immune Activation in a Model of Early Parkinson’s Disease. Biomedicines, 9(12), Article 1876. https://doi.org/10.3390/biomedicines9121876

Lillethorup, T. P., Iversen, P., Wegener, G., Doudet, D. J. M. & Landau, A. M. (2015). α2-adrenoceptor binding in Flinders-sensitive line compared with Flinders-resistant line and Sprague-Dawley rats. Acta Neuropsychiatrica (Print), 1-8. https://doi.org/10.1017/neu.2015.24

Kuebler, D., Waechter, T., Cabanel, N., Su, Z., Turkheimer, F. E., Dodel, R., Brooks, D. J., Oertel, W. H. & Gerhard, A. (2019). Widespread microglial activation in multiple system atrophy. Movement Disorders, 34(4), 564-568. https://doi.org/10.1002/mds.27620

Venkataraman, A. V., Mansur, A., Rizzo, G., Bishop, C., Lewis, Y., Kocagoncu, E., Lingford-Hughes, A., Huiban, M., Passchier, J., Rowe, J. B., Tsukada, H., Brooks, D. J., Martarello, L., Comley, R. A., Chen, L., Schwarz, A. J., Hargreaves, R., Gunn, R. N., Rabiner, E. A. & Matthews, P. M. (2022). Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer's disease. Science Translational Medicine, 14(658), Article eabk1051. https://doi.org/10.1126/scitranslmed.abk1051

Koole, M., Lewis, D. M., Buckley, C., Nelissen, N., Vandenbulcke, M., Brooks, D. J., Vandenberghe, R. & Van Laere, K. (2009). Whole-body biodistribution and radiation dosimetry of ¹⁸F-GE067: A radioligand for in vivo brain amyloid imaging. Journal of Nuclear Medicine, 50(5), 818-822. https://doi.org/10.2967/jnumed.108.060756

Pavese, N., Nuti, A., Bibbiani, F., Lucetti, C., Bonuccelli, U., Canapicchi, R. & Collavoli, P. (1994). White matter MRI hyperintensities in a hundred and twenty-nine consecutive migraine patients. Cephalalgia, 14(5), 342-345. https://doi.org/10.1046/j.1468-2982.1994.1405342.x

Piccini, P., Pavese, N., Canapicchi, R., Paoli, C., Del Dotto, P., Puglioli, M., Rossi, G. & Bonuccelli, U. (1995). White Matter Hyperintensities in Parkinson's Disease: Clinical Correlations. Archives of Neurology, 52(2), 191-194. https://doi.org/10.1001/archneur.1995.00540260097023

Mollenhauer, B., Rochester, L., Chen-Plotkin, A. & Brooks, D. (2014). What can biomarkers tell us about cognition in Parkinson's disease? Movement Disorders, 29(5), 622-33. https://doi.org/10.1002/mds.25846

Turner, M. R., Hammers, A., Allsop, J., Al-Chalabi, A., Shaw, C., Brooks, D. J., Leigh, N. P. & Andersen, P. (2007). Volumetric cortical loss in sporadic and familial amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis, 8(6), 343-347. https://doi.org/10.1080/17482960701538734

Ahsan, R. L., Allom, R., Gousias, I. S., Habib, H., Turkheimer, F. E., Free, S., Lemieux, L., Myers, R., Duncan, J. S., Brooks, D. J., Koepp, M. J. & Hammers, A. (2007). Volumes, spatial extents and a probabilistic atlas of the human basal ganglia and thalamus. NeuroImage, 38(2), 261-270. https://doi.org/10.1016/j.neuroimage.2007.06.004

Bennekou, P., Pedersen, O., Møller, A. & Christophersen, P. (2000). Volume control in sickle cells is facilitated by the novel anion conductance inhibitor NS1652. Blood, 95, 1842-1848.

Glud, A. N., Jakobsen, S., Landau, A., Alstrup, A. K. O. & Sorensen, J. C. (2019). Visualization of intrathecal delivery by PET-imaging. Journal of Neuroscience Methods, 317, 45-48. https://doi.org/10.1016/j.jneumeth.2019.02.003

Lawrence, A. D., Brooks, D. J. & Whone, A. L. (2013). Ventral striatal dopamine synthesis capacity predicts financial extravagance in Parkinson's disease. Frontiers in Psychology, 4, 90. https://doi.org/10.3389/fpsyg.2013.00090

Lawrence, A. D. & Brooks, D. J. (2014). Ventral striatal dopamine synthesis capacity is associated with individual differences in behavioral disinhibition. Frontiers in Behavioral Neuroscience, 8, 86. https://doi.org/10.3389/fnbeh.2014.00086

Gjedde, A., Aanerud, J., Peterson, E., Ashkanian, M., Iversen, P., Vafaee, M., Møller, A. & Borghammer, P. (2011). Variable ATP yields and uncoupling of oxygen consumption in human brain. Advances in Experimental Medicine and Biology, 701, 243-8. https://doi.org/10.1007/978-1-4419-7756-4_32

Pavese, N., Baracchini, G. & Bonuccelli, U. (1994). Valproate‐Withdrawal Induced Migraine. Headache: The Journal of Head and Face Pain, 34(7), 445. https://doi.org/10.1111/j.1526-4610.1994.hed3407445_1.x

Sabers, A., Nyengaard, J. R., Scheel-Krüger, J., Alstrup, A. K. O. & Møller, A. (2010). Valproat effects the number of cortical cells in the developing rat brain. Abstract from 9th ECE, Rhodos, Greece.

Giladi, N., Tal, J., Azulay, T., Rascol, O., Brooks, D. J., Melamed, E., Oertel, W., Poewe, W. H., Stocchi, F. & Tolosa, E. (2009). Validation of the Freezing of Gait Questionnaire in patients with Parkinson's disease. Movement Disorders, 24(5), 655-661. https://doi.org/10.1002/mds.21745

Buckley, C. J., Sherwin, P. F., Smith, A. P. L., Wolber, J., Weick, S. M. & Brooks, D. J. (2017). Validation of an electronic image reader training programme for interpretation of [F-18]flutemetamol beta- amyloid PET brain images. Nuclear Medicine Communications, 38(3), 234-241. https://doi.org/10.1097/MNM.0000000000000633

Nielsen, S. V., Dollerup, M. R., Baerentzen, S. L., Landau, A., Munk, O. L. & Alstrup, A. K. O. (2022). Validation and optimization of an automatic blood sampler for preclinical positron emission tomography (PET) research in domestic pigs. Laboratory Animals, 56(3), 287-291. Article 236772211049081. https://doi.org/10.1177/00236772211049081

Melichar, J. K., Hume, S. P., Williams, T. M., Daglish, M. R. C., Taylor, L. G., Ahmad, R., Malizia, A. L., Brooks, D. J., Myles, J. S., Lingford-Hughes, A. & Nutt, D. J. (2005). Using [¹¹C]diprenorphine to image opioid receptor occupancy by methadone in opioid addiction: Clinical and preclinical studies. Journal of Pharmacology and Experimental Therapeutics, 312(1), 309-315. https://doi.org/10.1124/jpet.104.072686

Lingford-Hughes, A. R., Myers, J. F., Watson, B. J., Reid, A. G., Kalk, N. J., Feeney, A., Hammers, A., Riaño Barros, D. A., McGinnity, C. J., Taylor, L. G., Rosso, L., Brooks, D. J., Turkheimer, F. E. & Nutt, D. J. (2016). Using [C-11]Ro15 4513 PET to characterise GABA-benzodiazepine receptors in opiate addiction: Similarities and differences with alcoholism. NeuroImage, 132, 1-7. https://doi.org/10.1016/j.neuroimage.2016.02.005

Hammers, A., Asselin, M. C., Hinz, R., Kitchen, I., Brooks, D. J., Duncan, J. S. & Koepp, M. J. (2007). Upregulation of opioid receptor binding following spontaneous epileptic seizures. Brain, 130(4), 1009-1016. https://doi.org/10.1093/brain/awm012

Scherfler, C., Khan, N. L., Pavese, N., Lees, A. J., Quinn, N. P., Brooks, D. J. & Piccini, P. P. (2006). Upregulation of dopamine D₂ receptors in dopaminergic drug-naive patients with Parkin gene mutations. Movement Disorders, 21(6), 783-788. https://doi.org/10.1002/mds.20811

Landau, A. M., Dyve, S., Jakobsen, S., Alstrup, A. K. O., Doudet, D. & Gjedde, A. (2012). Update: inhibition plots of [C-11]yohimbine binding yield consistent estimates of non-displaceable volumes of distribution in multiple tests. Abstract from The 9th International Symposium on Functional Neuroreceptor Mapping of the Living Brain, Baltimore, United States.

Bhatia, K., Brooks, D. J., Burn, D. J., Clarke, C. E., Grosset, D. G., MacMahon, D. G., Fer, J. P., Schapira, A. H. V., Stewart, D. & Williams, A. C. (2001). Updated guidelines for the management of Parlcinson's disease. Hospital Medicine, 62(8), 456-470. https://doi.org/10.12968/hosp.2001.62.8.1621

Schrag, A., Samuel, M., Caputo, E., Scaravilli, T., Troyer, M., Marsden, C. D., Thomas, D. G. T., Lees, A. J., Brooks, D. J. & Quinn, N. P. (1999). Unilateral pallidotomy for Parkinson's disease: Results after more than 1 year. Journal of Neurology Neurosurgery and Psychiatry, 67(4), 511-517. https://doi.org/10.1136/jnnp.67.4.511

Hyder, F., Herman, P., Bailey, C. J., Møller, A., Globinsky, R., Fulbright, R. K., Rothman, D. L. & Gjedde, A. (2015). Uniform distributions of glucose oxidation and oxygen extraction in gray matter of normal human brain: No evidence of regional differences of aerobic glycolysis. Journal of Cerebral Blood Flow and Metabolism, 36(5), 903-916. https://doi.org/10.1177/0271678X15625349

Perrild, H., Møller, A., Pedersen, H. & Siersbæk-Nielsen, K. (1988). Undetectable thyrotropin levels using immunoradiometric assay in L-dopa-treated patients. Nevrologicheskii Zhurnal, 235, 255.

Alstrup, A. K. O., Simonsen, M. & Landau, A. M. (2011). Type of anesthesia is important in rodent microPET studies: Effects of fentanyl-fluanisone-midazolam and isoflurane on measurements of dopamine D2/3 receptor binding in the rat brain. Poster session presented at ScandLAS Symposiet, Århus, Denmark.

Alstrup, A. K. O., Simonsen, M. & Landau, A. M. (2011). Type of anesthesia influences positron emission tomography measurements of dopamine D2/3 receptor binding in the rat brain. Scand J Lab Anim Sci, 38(3), 195-200.

Landau, A. M., Noer, O., Alstrup, A. K. O., Audrain, H., Wegener, G., Gjedde, A., Doudet, D. J. & Winterdahl, M. (2020). Type of Anaesthetic Influences [11C]MDL100,907 Binding to 5HT2A Receptors in Porcine Brain. Molecular Imaging and Biology, 22(4), 797-804. https://doi.org/10.1007/s11307-020-01476-x

Nicholl, D. J., Vaughan, J. R., Khan, N. L., Ho, S. L., Aldous, D. E. W., Lincoln, S., Farrer, M., Gayton, J. D., Davis, M. B., Piccini, P., Daniel, S. E., Lennox, G. G., Brooks, D. J., Williams, A. C. & Wood, N. W. (2002). Two large British kindreds with familial Parkinson's disease: A clinico-pathological and genetic study. Brain, 125(1), 44-57. https://doi.org/10.1093/brain/awf013

the PASADENA Investigators and Prasinezumab Study Group (2022). Trial of Prasinezumab in Early-Stage Parkinson's Disease. New England Journal of Medicine, 387(5), 421-432. https://doi.org/10.1056/NEJMoa2202867

Devos, D., Labreuche, J., Rascol, O., Corvol, J. C., Duhamel, A., Delannoy, P. G., Poewe, W., Compta, Y., Pavese, N., Ruzička, E., Dušek, P., Post, B., Bloem, B. R., Berg, D., Maetzler, W., Otto, M., Habert, M. O., Lehericy, S., Ferreira, J. ... FAIRPARK-II Study Group (2022). Trial of Deferiprone in Parkinson's Disease. New England Journal of Medicine, 387(22), 2045-2055. https://doi.org/10.1056/NEJMoa2209254

Lang, A. E., Siderowf, A. D., Macklin, E. A., Poewe, W., Brooks, D. J., Fernandez, H. H., Rascol, O., Giladi, N., Stocchi, F., Tanner, C. M., Postuma, R. B., Simon, D. K., Tolosa, E., Mollenhauer, B., Cedarbaum, J. M., Fraser, K., Xiao, J., Evans, K. C., Graham, D. L. ... SPARK Investigators (2022). Trial of Cinpanemab in Early Parkinson's Disease. The New England Journal of Medicine, 387(5), 408-420. https://doi.org/10.1056/NEJMoa2203395

Doder, M., Rabiner, E. A., Turjanski, N., Lees, A. J. & Brooks, D. J. (2003). Tremor in Parkinson's disease and serotonergic dysfunction: An ¹¹C-WAY 100635 PET study. Neurology, 60(4), 601-605. https://doi.org/10.1212/01.WNL.0000031424.51127.2B

Bain, P. G., Britton, T. C., Jenkins, I. H., Thompson, P. D., Rothwell, J. C., Thomas, P. K., Brooks, D. J. & Marsden, C. D. (1996). Tremor associated with benign IgM paraproteinaemic neuropathy. Brain, 119(3), 789-799. https://doi.org/10.1093/brain/119.3.789

Brooks, D. J., Agid, Y., Eggert, K., Widner, H., Østergaard, K. & Holopainen, A. (2005). Treatment of end-of-dose wearing-off in Parkinson's disease: Stalevo® (levodopa/carbidopa/entacapone) and levodopa/DDCI given in combination with Comtess®/Comtan® (entacapone) provide equivalent improvements in symptom control superior to that of traditional levodopa/DDCI treatment. European Neurology, 53(4), 197-202. https://doi.org/10.1159/000086479

Henrique Binda, K., Landau, A. M., Chacur, M., Brooks, D. J. & Cristiano Real, C. (2023). Treadmill exercise modulates nigral and hippocampal cannabinoid receptor type 1 in the 6-OHDA model of Parkinson's disease. Brain Research, 1814, Article 148436. https://doi.org/10.1016/j.brainres.2023.148436

Sawle, G. V., Bloomfield, P. M., Ourklund, A. B., Brooks, D. J., Brundin, P., Leenders, K. L., Lindvall, O., Marsden, C. D., Rehncrona, S., Widner, H. & Frackowiak, R. S. J. (1992). Transplantation of fetal dopamine neurons in Parkinson's disease: PET {¹⁸F}6‐L‐fluorodopa studies in two patients with putaminal implants. Annals of Neurology, 31(2), 166-173. https://doi.org/10.1002/ana.410310207

Piccini, P., Pavese, N., Bonuccelli, U., Distante, A., Palombo, C. & Pittella, G. (1995). Transcranial Doppler Ultrasound in Migraine and Tension-Type Headache After Apomorphine Administration: Double-Blind Crossover Versus Placebo Study. Cephalalgia, 15(5), 399-403. https://doi.org/10.1046/j.1468-29821995.1505399.x

Piccini, P., Pavese, N., Palombo, C., Pittella, G., Distante, A. & Bonuccelli, U. (1995). Transcranial Doppler ultrasound in migraine and tension‐type headache after apomorphine administration: double‐blind crossover versus placebo study. Cephalalgia, 15(5), 399-403. https://doi.org/10.1046/j.1468-2982.1995.1505399.x

Pavese, N., Rodemark, S., Tai, Y. F., Yousif, N., Nandi, D. & Bain, P. G. (2016). Traditional trial-and-error versus neuroanatomical-3D-image software-assisted deep brain stimulation programming in patients with Parkinson's disease. Movement Disorders, 31, S30-S31.

Pavese, N., Tai, Y. F., Yousif, N., Nandi, D. & Bain, P. G. (2020). Traditional Trial and Error versus Neuroanatomic 3-Dimensional Image Software-Assisted Deep Brain Stimulation Programming in Patients with Parkinson Disease. World Neurosurgery, 134, e98-e102. https://doi.org/10.1016/j.wneu.2019.09.106

Ledingham, D., Sathyanarayana, S., Stewart, C. B., Iredale, R., Foster, V., Galley, D., Baker, M. & Pavese, N. (2025). Tracking Motor Progression and Device-Aided Therapy Eligibility in Parkinson's Disease. Annals of Clinical and Translational Neurology. Advance online publication. https://doi.org/10.1002/acn3.70188

Holden, J. E., Jakobsen, S., Alstrup, A. K. O., Doudet, D. & Landau, A. M. (2011). Tracer kinetic responses to propofol-induced reduction of brain perfusion: Comparison of [11C]Yohimbine and [11C]SCH23390. Abstract from XXVth International Symposium on Cerebral Blood Flow, Metabolism and Function and the Xth International Conference on Quantification of Brain Function with PET, Barcelona, Spain.

Weeks, R. A., Turjanski, N. & Brooks, D. J. (1996). Tourette's syndrome: A disorder of cingulate and orbitofrontal function? QJM - Monthly Journal of the Association of Physicians, 89(6), 401-408.

Korbo, L., Andersen, B. B., Ladefoged, O. & Møller, A. (1993). Total numbers of various cell types in rat cerebellar cortex estimated using an unbiased stereological method. Brain Research, 609, 262-268.

Mouritzen-Dam, A., Møller, A., Scheel-Krüger, J., Jensen, L. H., Marescaux, C. & Vergnes, M. (1996). Total number of neurons in the ventro-lateral/posterior thalamic nuclei in a genetic petit mal-like rat strain. Epilepsy Res. Suppl., 12, 303-307.

Pakkenberg, B., Evans, S. M., Møller, A., Brændgaard, H. & Gundersen, H. J. (1989). Total number of neurons in human neocortex related to age and sex estimated by way of optical disectors. Acta Stereologica, 8, 251-256.

Strange, P., Møller, A., Ladefoged, O., Lam, H. R., Larsen, J.-J. & Arlien-Søborg, P. (1991). Total number and mean cell volume of neocortical neurons in rats exposed to 2,5-Hexanedione with and without acetone. Neurotoxicology and Teratology, 13, 401-6.

Arjmand, S., Wegener, G., Landau, A. M. & Eskelund, A. (2022). Tips and traps for behavioural animal experimentation. Acta Neuropsychiatrica, 34(5), 240-252. https://doi.org/10.1017/neu.2022.4

Jensen, L. H. & Møller, A. (1992). Time- and temperature-dependent forebrain ischemic damage in Mongolian gerbils. Acta Neurology Scand, 85, 187-190.

Bonuccelli, U., D'Avino, C., Caraccio, N., Del Guerra, P., Casolaro, A., Pavese, N., Del Dotto, P. & Monzani, F. (1999). Thyroid function and autoimmunity in Parkinson's disease: A study of 101 patients. Parkinsonism and Related Disorders, 5(1-2), 49-53. https://doi.org/10.1016/S1353-8020(99)00010-3

Perrild, H., Hegedüs, L., Båstrup, P. C., Kastberg, S., Feldt-Rasmussen, U., Bech, K., Madsen, M. H., Kayser, L., Møller, A. & Hansen, B. L. (1990). Thyroid autoimmunity in untreated and lithium treated patients with manic depressive disease. In The Thyroid gland, environment and autoimmunity: proceedings of the International Symposium on Thyroid Gland, Environment and Autoimmunity (pp. 331-2). Elsevier.

Hammers, A., Allom, R., Koepp, M. J., Free, S. L., Myers, R., Lemieux, L., Mitchell, T. N., Brooks, D. J. & Duncan, J. S. (2003). Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe. Human Brain Mapping, 19(4), 224-247. https://doi.org/10.1002/hbm.10123

Bhatia, K. P., Turjanski, N., Brooks, D. J., Marsden, C. D. & Thrush, D. (1996). The usefulness of functional imaging in movement disorders: An illustrative case [8]. Journal of Neurology Neurosurgery and Psychiatry, 60(3), 353-354. https://doi.org/10.1136/jnnp.60.3.353

Landau, A. M. (2010). The Ubiquitin Proteasome System in the Central Nervous System: From Physiology to Pathology - 2008 update: Chapter 17. VALIDITY OF TARGETING THE UBIQUITIN PROTEASOME SYSTEM IN THE ESTABLISHMENT OF NEW ANIMAL MODELS OF PARKINSON'S DISEASE . In M. Di Napoli & C. Wojcik (Eds.), The Ubiquitin Proteasome System in the Central Nervous System: From Physiology to Pathology - 2008 update (pp. 327-352). Nova Science Publishers.

Peterson, E., Gjedde, A., Doudet, D., Møller, A. & Linnet, J. (2008). The Thrill of Risk: Dopaminergic Neurotransmission in Pathological Gambling. Poster session presented at Aarhus University Hospital Research Day, Denmark.

Khoo, T. K., Yarnall, A. J., Duncan, G. W., Coleman, S., O'Brien, J. T., Brooks, D. J., Barker, R. A. & Burn, D. J. (2013). The spectrum of nonmotor symptoms in early Parkinson disease. Neurology, 80(3), 276-81. https://doi.org/10.1212/WNL.0b013e31827deb74

Jueptner, M., Jenkins, I. H., Brooks, D. J., Frackowiak, R. S. J. & Passingham, R. E. (1996). The sensory guidance of movement: A comparison of the cerebellum and basal ganglia. Experimental Brain Research, 112(3), 462-474. https://doi.org/10.1007/BF00227952

Schrag, A. E., Brooks, D. J., Brunt, E., Fuell, D., Korczyn, A., Poewe, W., Quinn, N. P., Rascol, O. & Stocchi, F. (1998). The safety of ropinirole, a selective nonergoline dopamine agonist, in patients with Parkinson's disease. Clinical Neuropharmacology, 21(3), 169-175.

Dagher, A., Owen, A. M., Boecker, H. & Brooks, D. J. (2001). The role of the striatum and hippocampus in planning: A PET activation study in Parkinson's disease. Brain, 124(5), 1020-1032.

Brett, M., Stein, J. F. & Brooks, D. J. (1998). The role of the lateral premotor cortex in conditional and imitated praxis. NeuroImage, 7(4 PART II).

Brooks, D. J. (1995). The role of the basal ganglia in motor control: contributions from PET. Journal of the Neurological Sciences, 128(1), 1-13. https://doi.org/10.1016/0022-510X(94)00206-4

Brooks, D. J. (2008). The role of structural and functional imaging in Parkinsonian states with a description of PET technology. Seminars in Neurology, 28(4), 435-445. https://doi.org/10.1055/s-0028-1083690

Ravina, B., Eidelberg, D., Ahlskog, J. E., Albin, R. L., Brooks, D. J., Carbon, M., Dhawan, V., Feigin, A., Fahn, S., Guttman, M., Gwinn-Hardy, K., McFarland, H., Innis, R., Katz, R. G., Kieburtz, K., Kish, S. J., Lange, N., Langston, J. W., Marek, K. ... Holloway, R. (2005). The role of radiotracer imaging in Parkinson disease. Neurology, 64(2), 208-215. https://doi.org/10.1212/01.WNL.0000149403.14458.7F

Brooks, D. J., Beaney, R. P. & Thomas, D. G. T. (1986). The role of Positron Emission Tomography in the study of cerebral tumors. Seminars in Oncology, 13(1), 83-93.

Smith, R., Wu, K., Hart, T., Loane, C., Brooks, D. J., Bjorklund, A., Odin, P., Piccini, P. & Politis, M. (2015). The role of pallidal serotonergic function in Parkinson's disease dyskinesias: a positron emission tomography study. Neurobiology of Aging, 36(4), 1736-1742. https://doi.org/10.1016/j.neurobiolaging.2014.12.037

Von Spiczak, S., Whone, A. L., Hammers, A., Asselin, M. C., Turkheimer, F., Tings, T., Happe, S., Paulus, W., Trenkwalder, C. & Brooks, D. J. (2005). The role of opioids in restless legs syndrome: An [¹¹C] diprenorphine PET study. Brain, 128(4), 906-917. https://doi.org/10.1093/brain/awh441

Pasqualetti, G., Brooks, D. J. & Edison, P. (2015). The Role of Neuroinflammation in Dementias. Current Neurology and Neuroscience Reports, 15(4), Article 17. https://doi.org/10.1007/s11910-015-0531-7

Piccini, P., Burn, D. J., Ceravolo, R., Maraganore, D. & Brooks, D. J. (1999). The role of inheritance in sporadic Parkinson's disease: Evidence from a longitudinal study of dopaminergic function in twins. Annals of Neurology, 45(5), 577-582. https://doi.org/10.1002/1531-8249(199905)45:5<577::AID-ANA5>3.0.CO;2-O

Schmidt, C., Skandali, N., Gleesborg, C., Kvamme, T. L., Schmidt, H., Frisch, K., Møller, A. & Voon, V. (2020). The role of dopaminergic and serotonergic transmission in the processing of primary and monetary reward. Neuropsychopharmacology, 45(9), 1490-1497. https://doi.org/10.1038/s41386-020-0702-3

Brooks, D. J., Carr, D. H. & Legg, N. J. (1987). The role of delayed computed tomographic scanning using high dose of contrast material in detecting cerebral demyelination in patients with multiple sclerosis in relapse and remission. British Journal of Radiology, 60(711), 295-297. https://doi.org/10.1259/0007-1285-60-711-295

Långström, B., Grahnen, A., Honoré, P. H., Borlak, J., Bergstrom, M., Nielsen, B., Vanderheyden, J., Watanabe, Y., Josephsson, R., Høilund-Carlsen, P. F., Schwaiger, M., Larson, S. M., Goldenberg, D. M., Melzer, A., Engler, H., Hicks, R., Sundin, A., Seppänen, M., Hedenstierna, G. ... Brooks, D. (2009). The risk of exaggerated risk aversion-a life and death struggle for molecular imaging. European journal of nuclear medicine and molecular imaging, 36(10), 1693-1694. https://doi.org/10.1007/s00259-009-1190-1

Ismail, R., Parbo, P., Madsen, L. S., Hansen, A. K., Hansen, K. V., Schaldemose, J. L., Kjeldsen, P. L., Stokholm, M. G., Gottrup, H., Eskildsen, S. F. & Brooks, D. J. (2020). The relationships between neuroinflammation, beta-amyloid and tau deposition in Alzheimer's disease: a longitudinal PET study. Journal of Neuroinflammation, 17(1), Article 151. https://doi.org/10.1186/s12974-020-01820-6

Lawrence, A. D., Weeks, R. A., Brooks, D. J., Andrews, T. C., Watkins, L. H. A., Harding, A. E., Robbins, T. W. & Sahakian, B. J. (1998). The relationship between striatal dopamine receptor binding and cognitive performance in Huntington's disease. Brain, 121(7), 1343-1355. https://doi.org/10.1093/brain/121.7.1343

Brooks, D. J., Salmon, E. P., Mathias, C. J., Quinn, N., Leenders, K. L., Bannister, R., Marsden, C. D. & Frackowiak, R. S. J. (1990). The relationship between locomotor disability, autonomic dysfunction, and the integrity of the striatal dopaminergic system in patients with multiple system atrophy, pure autonomic failure, and parkinson's disease, studied with pet. Brain, 113(5), 1539-1552. https://doi.org/10.1093/brain/113.5.1539

Kew, J. J. M., Goldstein, L. H., Leigh, P. N., Abrahams, S., Cosgrave, N., Passingham, R. E., Frackowiak, R. S. J. & Brooks, D. J. (1993). The relationship between abnormalities of cognitive function and cerebral activation in amyotrophic lateral sclerosis: A neuropsychological and positron emission tomography study. Brain, 116(6), 1399-1423. https://doi.org/10.1093/brain/116.6.1399

Carboncini, M. C., Manzoni, D., Strambi, S., Bonuccelli, U., Pavese, N., Andre, P. & Rossi, B. (2001). The relation between EMG activity and kinematic parameters strongly supports a role of the action tremor in parkinsonian bradykinesia. Movement Disorders, 16(1), 47-57. https://doi.org/10.1002/1531-8257(200101)16:1<47::AID-MDS1012>3.0.CO;2-V

Morrish, P. K., Sawle, G. V. & Brooks, D. J. (1996). The rate of progression of Parkinson's disease. A longitudinal [18F]DOPA PET study. Advances in neurology, 69, 427-431.

Gelosa, G. & Brooks, D. J. (2012). The prognostic value of amyloid imaging. European Journal of Nuclear Medicine and Molecular Imaging, 39(7), 1207-19. https://doi.org/10.1007/s00259-012-2108-x

Pavese, N. & the Parkinson's Progression Markers Initiative (2018). The Parkinson's progression markers initiative (PPMI) – establishing a PD biomarker cohort. Annals of Clinical and Translational Neurology, 5(12), 1460-1477. https://doi.org/10.1002/acn3.644

Damholdt, M. F., Callesen, M. B. & Møller, A. (2013). The parkinsonian personality: a role of depression?. Abstract from 20th IAGG World Congress of Gerontology and Geriatrics, Seoul, Korea, Republic of. http://www.iagg2013.org/

Ray Chaudhuri, K., Leta, V., Bannister, K., Brooks, D. J. & Svenningsson, P. (2023). The noradrenergic subtype of Parkinson disease: from animal models to clinical practice. Nature Reviews Neurology, 19(6), 333-345. https://doi.org/10.1038/s41582-023-00802-5

Gundersen, H. J. G., Bagger, P., Bendtsen, T. F., Evans, S. M., Korbo, L., Marcussen, N., Møller, A., Nielsen, K., Nyengaard, J. R., Pakkenberg, B., Sørensen, F. B., Vesterby, A. & West, M. J. (1988). The new stereological tools: disector, fractionator, nucleator and point-sampled intercepts and their use in pathological research and diagnosis. APMIS Supplementum, 96, 857-881.

Landau, A. M., Dyve, S., Alstrup, A. K. O., Jakobsen, S., Simonsen, M., Møller, A., Videbech, P., Wegener, G., Gjedde, A. & Doudet, D. (2011). The minipig as an animal model to study antidepressant pharmacology by PET. Abstract from NIDA, Florida, United States.

Sawle, G. V., Lees, A. J., Hymas, N. F., Brooks, D. J. & Frackowiak, R. S. J. (1993). The metabolic effects of limbic leucotomy in Gilles de la Tourette syndrome. Journal of Neurology, Neurosurgery & Psychiatry, 56(9), 1016-1019. https://doi.org/10.1136/jnnp.56.9.1016

Barker, R. A., Mason, S. L., Harrower, T. P., Swain, R. A., Ho, A. K., Sahakian, B. J., Mathur, R., Elneil, S., Thornton, S., Hurrelbrink, C., Armstrong, R. J., Tyers, P., Smith, E., Carpenter, A., Piccini, P., Tai, Y. F., Brooks, D. J., Pavese, N., Watts, C. ... NEST-UK collaboration (2013). The long-term safety and efficacy of bilateral transplantation of human fetal striatal tissue in patients with mild to moderate Huntington's disease. Journal of Neurology, Neurosurgery & Psychiatry, 84(6), 657-65. https://doi.org/10.1136/jnnp-2012-302441

Stewart, C. B., Ledingham, D., Foster, V. K., Anderson, K. N., Sathyanarayana, S., Galley, D., Pavese, N. & Pasquini, J. (2023). The longitudinal progression of autonomic dysfunction in Parkinson's disease: A 7-year study. Frontiers in Neurology, 14, Article 1155669. https://doi.org/10.3389/fneur.2023.1155669

Pasquini, J., Brooks, D. J. & Pavese, N. (2025). The involvement of the cholinergic system in Parkinson disease. In C. Cuello (Ed.), Cholinergic Involvement in Neurodegenerative Diseases (pp. 215-229). Elsevier. https://doi.org/10.1016/B978-0-443-19088-9.00001-9

Arjmand, S., Landau, A. M., Varastehmoradi, B., Andreatini, R., Joca, S. & Wegener, G. (2022). The intersection of astrocytes and the endocannabinoid system in the lateral habenula: on the fast-track to novel rapid-acting antidepressants. Molecular Psychiatry, 27(8), 3138–3149 . https://doi.org/10.1038/s41380-022-01598-4

Pakkenberg, B., Andersen, B. B., Jensen, G. B., Korbo, L., Mouton, P. R., Møller, A., Regeur, L. & Øster, S. (1992). The impact of the new stereology on the neurosciences - neurostereology. Acta Stereology Suppl, 11, 157-164.

Sawle, G. V., Wroe, S. J., Lees, A. J., Brooks, D. J. & Frackowiak, R. S. J. (1992). The identification of presymptomatic parkinsonism: Clinical and {¹⁸F}dopa positron emission tomography studies in an irish kindred. Annals of Neurology, 32(5), 609-617. https://doi.org/10.1002/ana.410320503

Tai, Y. F., Scherfler, C., Brooks, D. J., Sawamoto, N. & Castiello, U. (2004). The Human Premotor Cortex Is 'Mirror' only for Biological Actions. Current Biology, 14(2), 117-120. https://doi.org/10.1016/j.cub.2004.01.005

Bro, A., Sørensen, J. C. H., Nielsen, M. S., Rosendahl, F., Deding, D., Ettrup, K. S., Jensen, K. N., Jørgensen, R. L., Glud, A. N., Meidahl, A. C. N., Meier, K., Moberg Fitting, L., Møller, A., Alstrup, A. K. O., Østergaard, L. & Bjarkam, C. R. (2012). The Göttingen minipig in translational neuroscience. Ellegaard Newsletter, 38, 8-9.

Jabbari, E., Woodside, J., Tan, M. M. X., Pavese, N., Bandmann, O., Ghosh, B. C. P., Massey, L. A., Capps, E., Warner, T. T., Lees, A. J., Revesz, T., Holton, J. L., Williams, N. M., Grosset, D. G. & Morris, H. R. (2019). The genetic and clinico-pathological profile of early-onset progressive supranuclear palsy. Movement Disorders, 34(9), 1307-1314. https://doi.org/10.1002/mds.27786

Callesen, M. B., Thomsen, K. R., Linnet, J. & Møller, A. (2007). The Gambling Reducing Slot Machine. In Sixth Annual OAK Meeting for Danish Brain Research Laboratories

Helmich, R. C., Vaillancourt, D. E. & Brooks, D. J. (2018). The future of brain imaging in Parkinson's disease. Journal of Parkinson's Disease, 8(s1), S47-S51. https://doi.org/10.3233/JPD-181482

Banati, R. B., Görres, G., Brooks, D. J., Aggleton, J. P. & Grasby, P. M. (1997). The functional anatomy of sensory integration in man. NeuroImage, 5(4 PART II).

Brooks, D. J. & Samuel, M. (2000). The effects of surgical treatment of Parkinson's disease on brain function: PET findings. Neurology, 55(12 SUPPL. 6).

Fricker, R. A., Torres, E. M., Hume, S. P., Myers, R., Opacka-Juffrey, J., Ashworth, S., Brooks, D. J. & Dunnett, S. B. (1997). The effects of donor stage on the survival and function of embryonic striatal grafts in the adult rat brain. II. Correlation between positron emission tomography and reaching behaviour. Neuroscience, 79(3), 711-721. https://doi.org/10.1016/S0306-4522(96)00657-4

White, R. P., Hindley, C., Bloomfield, P. M., Cunningham, V. J., Vallance, P., Brooks, D. J. & Markus, H. S. (1999). The effect of the nitric oxide synthase inhibitor L-NMMA on basal CBF and vasoneuronal coupling in man: A PET study. Journal of Cerebral Blood Flow and Metabolism, 19(6), 673-678. https://doi.org/10.1097/00004647-199906000-00011

White, R. P., Deane, C., Hindley, C., Bloomfield, P. M., Cunningham, V. J., Vallance, P., Brooks, D. J. & Markus, H. S. (2000). The effect of the nitric oxide donor glyceryl trinitrate on global and regional cerebral blood flow in man. Journal of the Neurological Sciences, 178(1), 23-28. https://doi.org/10.1016/S0022-510X(00)00357-9

Martis, L.-S., Tran, T. P., Bouzinova, E., Christiansen, S. L., Møller, A., Holmes, M. C. & Wiborg, O. (2018). The effect of rat strain and stress exposure on performance in touchscreen tasks. Physiology & Behavior, 184, 83-90. https://doi.org/10.1016/j.physbeh.2017.11.010

Jenkins, I. H., Passingham, R. E. & Brooks, D. J. (1997). The effect of movement frequency on cerebral activation: A positron emission tomography study. Journal of the Neurological Sciences, 151(2), 195-205. https://doi.org/10.1016/S0022-510X(97)00145-7

Boecker, H., Wills, A. J., Ceballos-Baumann, A., Samuel, M., Thompson, P. D., Findley, L. J. & Brooks, D. J. (1996). The effect of ethanol on alcohol-responsive essential tremor: A position emission tomography study. Annals of Neurology, 39(5), 650-658. https://doi.org/10.1002/ana.410390515

Sawle, G. V., Burn, D. J., Morrish, P. K., Lammertsma, A. A., Snow, B. J., Luthra, S., Osman, S. & Brooks, D. J. (1994). The effect of entacapone (OR-611)on brain [¹⁸F]-6-L-fluorodopa metabolism: Implications for levodopa therapy of Parkinson’s disease. Neurology, 44(7), 1292-1297. https://doi.org/10.1212/wnl.44.7.1292

Ismail, R., Hansen, A. K., Parbo, P., Brændgaard, H., Gottrup, H., Brooks, D. J. & Borghammer, P. (2018). The Effect of 40-Hz Light Therapy on Amyloid Load in Patients with Prodromal and Clinical Alzheimer's Disease. International Journal of Alzheimer's Disease, 2018, 6852303. Article 6852303. https://doi.org/10.1155/2018/6852303

Brooks, D. J. (1998). The early diagnosis of Parkinson's disease. Annals of Neurology, 44(3 SUPPL. 1).

Josefsen, L. G., Doudet, D., Møller, A., Gjedde, A., Linnet, J. & Vuust, P. (2009). The Drummer's High: - dopaminfrigivelse hos en jazz-trommeslager. Poster session presented at Forskningens dag, AUH, Aarhus, Denmark.

Josefsen, L. G., Doudet, D., Møller, A., Gjedde, A., Linnet, J. & Vuust, P. (2009). The Drummer's High: the role of midbrain dopamine in live musical performance. Abstract from Neurodag.

Galgani, A., Lombardo, F., Frijia, F., Martini, N., Tognoni, G., Pavese, N. & Giorgi, F. S. (2024). The degeneration of locus coeruleus occurring during Alzheimer’s disease clinical progression: a neuroimaging follow-up investigation. Brain Structure & Function, 229(5), 1317-1325. https://doi.org/10.1007/s00429-024-02797-1

Danielsen, E. H., Cumming, P., Andersen, F., Bender, D., Brevig, T., Falborg, L., Gee, A., Gillings, N. M., Hansen, S. B., Hermansen, F., Johansen, J., Johansen, T. E., Dahl-Jørgensen, A., Jørgensen, H. A., Meyer, M., Munk, O. L., Pedersen, E. B., Poulsen, P. H., Rodell, A. B. ... Møller, A. (2000). The DaNeX Study of Embryonic Mesencephalic Dopaminergic Tissue Grafted to a Minipig model of Parkinson's disease: Preliminary Findings of Effect of MPTP-Poisoning on Striatal Dopaminergic Markers. Cell Transplantation, 9(2), 247-259. https://doi.org/10.1177/096368970000900210

Senda, M., Brooks, D. J., Farrar, G., Somer, E. J., Paterson, C. L., Sasaki, M. & McParland, B. J. (2015). The clinical safety, biodistribution and internal radiation dosimetry of flutemetamol (F-18) injection in healthy Japanese adult volunteers. Annals of nuclear medicine, 29(7), 627-635. https://doi.org/10.1007/s12149-015-0986-2

Brooks, D. J. (1991). The clinical role of PET in cerebrovascular disease. Neurosurgical Review, 14(2), 91-96. https://doi.org/10.1007/BF00313030

Pasquini, J., Deuschl, G., Pecori, A., Salvadori, S., Ceravolo, R. & Pavese, N. (2023). The Clinical Profile of Tremor in Parkinson's Disease. Movement Disorders Clinical Practice, 10(10), 1496-1506. https://doi.org/10.1002/mdc3.13845

Sathyanarayana, S., Pavese, N. & Ledingham, D. (2025). The cholinergic system in dementia with Lewy bodies. In C. Cuello (Ed.), Cholinergic Involvement in Neurodegenerative Diseases (pp. 231-245). Elsevier. https://doi.org/10.1016/B978-0-443-19088-9.00008-1

Pasquini, J., Brooks, D. J. & Pavese, N. (2021). The Cholinergic Brain in Parkinson's Disease. Movement Disorders Clinical Practice, 8(7), 1012-1026. https://doi.org/10.1002/mdc3.13319

Wu, K., O'Keeffe, D., Politis, M., O'Keeffe, G. C., Robbins, T. W., Bose, S. K., Brooks, D. J., Piccini, P. & Barker, R. A. (2012). The catechol-O-methyltransferase Val(158)Met polymorphism modulates fronto-cortical dopamine turnover in early Parkinson's disease: a PET study. Brain, 135(Pt 8), 2449-57. https://doi.org/10.1093/brain/aws157

Piccini, P., Brooks, D. J., Korpela, K., Pavese, N., Karlsson, M. & Gordin, A. (2000). The catechol-O-methyltransferase (COMT) inhibitor entacapone enhances the pharmacokinetic and clinical response to Sinemet CR in Parkinson's disease. Journal of Neurology Neurosurgery and Psychiatry, 68(5), 589-594. https://doi.org/10.1136/jnnp.68.5.589

Østergaard, L., Aamand, R., Gutiérrez Jiménez, E., Ho, Y. C. L., Blicher, J., Madsen, S. M., Nagenthiraja, K., Dalby, R. B., Drasbek, K. R., Møller, A., Brændgaard, H., Mouridsen, K., Jespersen, S. N., Jensen, M. S. & West, M. J. (2013). The capillary dysfunction hypothesis of Alzheimer's disease. Neurobiology of Aging, 34(4), 1018-31. https://doi.org/10.1016/j.neurobiolaging.2012.09.011

Vidailhet, M., Stocchi, F., Rothwell, J. C., Thompson, P. D., Day, B. L., Brooks, D. J. & Marsden, C. D. (1993). The bereitschaftspotential preceding simple foot movement and initiation of gait in Parkinson's disease. Neurology, 43(9), 1784-1788.

Alstrup, A. K. O., Lillethorup, T. P., Landau, A. & Afzelius, P. (2024). The arterial blood sampling associated with PET imaging studies can lead to post-scan complications in Göttingen minipigs. Scandinavian Journal of Laboratory Animal Science, 50(2), 6-12. https://doi.org/10.23675/sjlas.v50i.22397

Brooks, D. J. (2015). The Anatomy of Parkinsonian Disorders. In Social Cognitive Neuroscience, Cognitive Neuroscience, Clinical Brain Mapping (Vol. 3, pp. 759-767). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-397025-1.00087-7

Winterdahl, M., Noer, O., Orlowski, D., Jakobsen, S., Alstrup, A. K. O., Scheel-Krüger, J., Kringelbach, M. L., Møller, A. & Landau, A. M. (2017). The “addicted” minipig brain: Sugar intake decreases dopamine D2/3 receptor availability in brain regions implicated in addiction. Poster session presented at 1st Annual Research Meeting, Aarhus, Denmark.

Pakkenberg, B., Møller, A., Gundersen, H. J., Dam, A. M. & Pakkenberg, H. (1991). The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method. Journal of Neurology, Neurosurgery & Psychiatry, 54, 30-3.

Scott, G., Hellyer, P. J., Ramlackhansingh, A. F., Brooks, D. J., Matthews, P. M. & Sharp, D. J. (2015). Thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage. Journal of Neuroinflammation, 12(1), Article 224. https://doi.org/10.1186/s12974-015-0445-y

Riaño Barros, D. A., McGinnity, C. J., Rosso, L., Heckemann, R. A., Howes, O. D., Brooks, D. J., Duncan, J. S., Turkheimer, F. E., Koepp, M. J. & Hammers, A. (2014). Test-retest reproducibility of cannabinoid-receptor type 1 availability quantified with the PET ligand [¹¹C]MePPEP. NeuroImage, 97, 151-62. https://doi.org/10.1016/j.neuroimage.2014.04.020

Nuti, A., Maremmani, C., Ceravolo, R., Pavese, N., Bonuccelli, U. & Muratorio, A. (1991). TERAPIA CON DESAMETAZONE NELLA COREA DI HUNTINGTON: RISULTATI PRELIMINARI. Rivista di Neurologia, 61(6), 225-227.

Kapur, N. & Brooks, D. J. (1999). Temporally-specific retrograde amnesia in two cases of discrete bilateral hippocampal pathology. Hippocampus, 9(3), 247-254. https://doi.org/10.1002/(SICI)1098-1063(1999)9:3<247::AID-HIPO5>3.0.CO;2-W

van Hartevelt, T. J., Kjærgaard, T., Jegindø, E.-M. E., Stevner, A., Mohseni, H., Woolrich, M., Margot, C., Møller, A., Aziz, T., Ovesen, T. & Kringelbach, M. L. (2013). Temporal aspects of the sense of smell: A study using magnetoencephalography. Poster session presented at Society for Neuroscience, San Diego, United States.

Brooks, D. J. (2008). Technology Insight: Imaging neurodegeneration in Parkinson's disease. Nature Clinical Practice Neurology, 4(5), 267-277. https://doi.org/10.1038/ncpneuro0773

Edison, P., Hinz, R. & Brooks, D. J. (2011). Technical aspects of amyloid imaging for Alzheimer's disease. Alzheimer's Research & Therapy, 3(4), Article 25. https://doi.org/10.1186/alzrt87

Hansen, A. K., Parbo, P., Ismail, R., Østergaard, K., Brooks, D. J. & Borghammer, P. (2020). Tau Tangles in Parkinson's Disease: A 2-Year Follow-Up Flortaucipir PET Study. Journal of Parkinson's Disease, 10(1), 161-171. https://doi.org/10.3233/JPD-191774

Dani, M., Brooks, D. J. & Edison, P. (2016). Tau imaging in neurodegenerative diseases. European journal of nuclear medicine and molecular imaging, 43(6), 1139-1150. https://doi.org/10.1007/s00259-015-3231-2

Dani, M., Wood, M., Mizoguchi, R., Fan, Z., Edginton, T., Hinz, R., Win, Z., Brooks, D. J. & Edison, P. (2019). Tau Aggregation Correlates with Amyloid Deposition in Both Mild Cognitive Impairment and Alzheimer's Disease Subjects. Journal of Alzheimer's Disease, 70(2), 455-465. https://doi.org/10.3233/JAD-181168

Varning, T., Christophersen, P., Møller, A., Peters, D., Axelsson, O. & Nielsen, E. Ø. (1996). Synthesis and biological actitivy of the neuronal calcium channel blocker 2-amino-1-(2,5-dimethoxyphenyl)-5-trifluoromethyl benzimidazole (NS-649). Bioorganic & Medicinal Chemistry Letters, 6, 245-248.

Rossi, R., Arjmand, S., Bærentzen, S. L., Gjedde, A. & Landau, A. (2022). Synaptic Vesicle Glycoprotein 2A: Features and Functions. Frontiers in Neuroscience, 16, Article 864514. https://doi.org/10.3389/fnins.2022.864514

Andersen, K. B., Hansen, A. K., Schacht, A. C., Horsager, J., Gottrup, H., Klit, H., Danielsen, E. H., Poston, K. L., Pavese, N., Brooks, D. J. & Borghammer, P. (2023). Synaptic Density and Glucose Consumption in Patients with Lewy Body Diseases: An [¹¹C]UCB-J and [¹⁸F]FDG PET Study. Movement disorders : official journal of the Movement Disorder Society, 38(5), 796-805. https://doi.org/10.1002/mds.29375

Politis, M., Sauerbier, A., Loane, C., Pavese, N., Martin, A., Corcoran, B., Brooks, D. J., Ray Chaudhuri, K. & Piccini, P. (2017). Sustained striatal dopamine levels following intestinal levodopa infusions in Parkinson's disease patients. Movement Disorders, 32(2), 235-240. https://doi.org/10.1002/mds.26848

Dani, M., Brooks, D. J. & Edison, P. (2017). Suspected non-Alzheimer's pathology - Is it non-Alzheimer's or non-amyloid? Ageing Research Reviews, 36, 20-31. https://doi.org/10.1016/j.arr.2017.02.003

Freed, C. R., Breeze, R. E., Rosenberg, N. L., Schneck, S. A., Kriek, E., qi, J. X., Lone, T., Zhang, Y. B., Snyder, J. A., Wells, T. H., Ramig, L. O., Thompson, L., Mazziotta, J. C., Huang, S. C., Grafton, S. T., Brooks, D., Sawle, G., Schroter, G. & Ansari, A. A. (1992). Survival of Implanted Fetal Dopamine Cells and Neurologic Improvement 12 to 46 Months after Transplantation for Parkinson's Disease. New England Journal of Medicine, 327(22), 1549-1555. https://doi.org/10.1056/NEJM199211263272202

Hvingelby, V. S. & Pavese, N. (2024). Surgical Advances in Parkinson’s Disease. Current Neuropharmacology, 22(6), 1033-1046. https://doi.org/10.2174/1570159X21666221121094343

Bertelsen, F., Folloni, D., Møller, A., Landau, A. M., Scheel-Krüger, J. & Winterdahl, M. (2017). Suppressed play behaviour and decreased oxytocin receptor binding in the amygdala after prenatal exposure to low-dose valproic acid. Behavioural Pharmacology, 28(6), 450-457. https://doi.org/10.1097/FBP.0000000000000316

Vandenberghe, R., Van Laere, K., Ivanoiu, A., Salmon, E., Bastin, C., Triau, E., Hasselbalch, S., Law, I., Andersen, A., Korner, A., Minthon, L., Garraux, G., Nelissen, N., Bormans, G., Buckley, C., Owenius, R., Thurfjell, L., Farrar, G. & Brooks, D. J. (2010). ¹⁸F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment a phase 2 trial. Annals of Neurology, 68(3), 319-329. https://doi.org/10.1002/ana.22068

Berding, G., Brücke, T., Odin, P., Brooks, D. J., Kolbe, H., Gielow, P., Harke, H., Knoop, B. O., Dengler, R. & Knapp, W. H. (2003). [¹²³I]β-CIT SPECT imaging of dopamine and serotonin transporters in Parkinson's disease and multiple system atrophy. Nuklearmedizin, 42(1), 31-38.

Turner, M. R., Rabiner, E. A., Hammers, A., Al-Chalabi, A., Grasby, P. M., Shaw, C. E., Brooks, D. J. & Leigh, P. N. (2005). [¹¹C]-WAY100635 PET demonstrates marked 5-HT_1A receptor changes in sporadic ALS. Brain, 128(4), 896-905. https://doi.org/10.1093/brain/awh428

Baun, A. M., Firbank, M., Hinz, R., Terkelsen, M. H., Iranzo, A., Gaig, C., Tolosa, E., Brooks, D. J., Pavese, N. & Keogh, M. (2025). [¹¹C](R)-PK11195 Positron Emission Tomography Imaging of Skull Inflammation in Isolated Rapid-Eye-Movement Sleep Behavior Disorder. Movement disorders : official journal of the Movement Disorder Society. Advance online publication. https://doi.org/10.1002/mds.70133

Banati, R. B., Goerres, G. W., Myers, R., Gunn, R. N., Turkheimer, F. E., Kreutzberg, G. W., Brooks, D. J., Jones, T. & Duncan, J. S. (1999). [¹¹C] (R)-PK11195 positron emission tomography imaging of activated microglia in vivo in Rasmussen's encephalitis. Neurology, 53(9), 2199-2203.

Gerhard, A., Banati, R. B., Goerres, G. B., Cagnin, A., Myers, R., Gunn, R. N., Turkheimer, F., Good, C. D., Mathias, C. J., Quinn, N., Schwarz, J. & Brooks, D. J. (2003). [¹¹C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy. Neurology, 61(5), 686-689. https://doi.org/10.1212/01.WNL.0000078192.95645.E6

Rodda, J., Okello, A., Edison, P., Dannhauser, T., Brooks, D. J. & Walker, Z. (2010). ¹¹C-PIB PET in subjective cognitive impairment. European Psychiatry, 25(2), 123-125. https://doi.org/10.1016/j.eurpsy.2009.07.011

Rinne, J. O., Brooks, D. J., Rossor, M. N., Fox, N. C., Bullock, R., Klunk, W. E., Mathis, C. A., Blennow, K., Barakos, J., Okello, A. A., de LIano, S. R. M., Liu, E., Koller, M., Gregg, K. M., Schenk, D., Black, R. & Grundman, M. (2010). ¹¹C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study. The Lancet Neurology, 9(4), 363-372. https://doi.org/10.1016/S1474-4422(10)70043-0

Kuebler, L., Buss, S., Leonov, A., Ryazanov, S., Schmidt, F., Maurer, A., Weckbecker, D., Landau, A. M., Lillethorup, T. P., Bleher, D., Saw, R. S., Pichler, B. J., Griesinger, C., Giese, A. & Herfert, K. (2021). [¹¹C]MODAG-001-towards a PET tracer targeting α-synuclein aggregates. European Journal of Nuclear Medicine and Molecular Imaging, 48(6), 1759–1772 . https://doi.org/10.1007/s00259-020-05133-x

Koepp, M. J., Richardson, M. P., Labbé, C., Brooks, D. J., Cunningham, V. J., Ashburner, J., Van Paesschen, W., Revesz, T. & Duncan, J. S. (1997). ¹¹C-flumazenil PET, volumetric MRI, and quantitative pathology in mesial temporal lobe epilepsy. Neurology, 49(3), 764-773. https://doi.org/10.1212/WNL.49.3.764

Hammers, A., Panagoda, P., Heckemann, R. A., Kelsch, W., Turkheimer, F. E., Brooks, D. J., Duncan, J. S. & Koepp, M. J. (2008). [¹¹C]Flumazenil PET in temporal lobe epilepsy: Do we need an arterial input function or kinetic modeling? Journal of Cerebral Blood Flow and Metabolism, 28(1), 207-216. https://doi.org/10.1038/sj.jcbfm.9600515

Koepp, M. J., Hammers, A., Labbé, C., Woermann, F. G., Brooks, D. J. & Duncan, J. S. (2000). ¹¹C-flumazenil PET in patients with refractory temporal lobe epilepsy and normal MRI. Neurology, 54(2), 332-339.

Richardson, M. P., Koepp, M. J., Brooks, D. J. & Duncan, J. S. (1998). ¹¹C-flumazenil PET in neocortical epilepsy. Neurology, 51(2), 485-492. https://doi.org/10.1212/WNL.51.2.485

Weeks, R. A., Cunningham, V. J., Piccini, P., Waters, S., Harding, A. E. & Brooks, D. J. (1997). ¹¹C-diprenorphine binding in Huntington's disease: A comparison of region of interest analysis with statistical parametric mapping. Journal of Cerebral Blood Flow and Metabolism, 17(9), 943-949. https://doi.org/10.1097/00004647-199709000-00003

Winterdahl, M., Noer, O., Orlowski, D., Schacht, A. C., Jakobsen, S., Alstrup, A. K. O., Gjedde, A. & Landau, A. (2019). Sucrose intake lowers μ-opioid and dopamine D2/3 receptor availability in porcine brain. Scientific Reports, 9(1), Article 16918. https://doi.org/10.1038/s41598-019-53430-9

Pasquini, J., Firbank, M. J., Best, L., Foster, V., Stewart, C., Silani, V., Durcan, R., Roberts, G., Petrides, G., Ceravolo, R., Brooks, D. J., Anderson, K. N. & Pavese, N. (2025). Substantia nigra and locus coeruleus microstructural abnormalities in isolated rapid eye movement sleep behaviour disorder and Parkinson's disease. Brain Communications, 7(1), fcaf023. Article fcaf023. https://doi.org/10.1093/braincomms/fcaf023

Cintra, A., Aguirre, J. A., Finnman, U.-B., Hagman, M., Agnati, L. F., Höglund, C., Møller, A. & Fuxe, K. (1999). Subchronic toluene exposure in low concentrations produces signs of reduced dysfunction in the 6-hydroxydopamine lesioned nigrostriatal dopaminergic system of the rat. Neuroscience Letter, 274, 5-8.

Bærentzen, S. L., Thomsen, J. B., Thomsen, M. B., Jakobsen, S., Simonsen, M. T., Wegener, G., Brooks, D. J. & Landau, A. M. (2024). Subanesthetic S-ketamine does not acutely alter striatal dopamine transporter binding in healthy Sprague Dawley female rats. Synapse, 78(4), Article e22294. https://doi.org/10.1002/syn.22294

Jesuthasan, A., Garcia, L. R. & Pavese, N. (2022). Studying cognitive function in patients with a long-standing diagnosis of SWEDD. Journal of the Neurological Sciences, 441, Article 120353. https://doi.org/10.1016/j.jns.2022.120353

Brooks, D. J., Beaney, R. P., Thomas, D. G. T., Marshall, J. & Jones, T. (1986). Studies on regional cerebral pH in patients with cerebral tumours using continuous inhalation of ¹¹CO₂ and positron emission tomography. Journal of Cerebral Blood Flow and Metabolism, 6(5), 529-535. https://doi.org/10.1038/jcbfm.1986.98

Brooks, D. J., Leenders, K. L., Head, G., Marshall, J., Legg, N. J. & Jones, T. (1984). Studies on regional cerebral oxygen utilisation and cognitive function in multiple sclerosis. Journal of Neurology, Neurosurgery & Psychiatry, 47(11), 1182-1191. https://doi.org/10.1136/jnnp.47.11.1182

Brooks, D. J., Beaney, R. P., Lammertsma, A. A., Turton, D. R., Marshall, J., Thomas, D. G. T. & Jones, T. (1986). Studies on regional cerebral haematocrit and blood flow in patients with cerebral tumours using positron emission tomography. Microvascular Research, 31(3), 267-276. https://doi.org/10.1016/0026-2862(86)90016-6

Brooks, D. J., Beaney, R. P., Powell, M., Leenders, K. L., Crockard, H. A., Thomas, D. G. T., Marshall, J. & Jones, T. (1986). Studies on cerebral oxygen metabolism, blood flow, and blood volume, in patients with hydrocephalus before and after surgical decompression, using positron emission tomography. Brain, 109(4), 613-628. https://doi.org/10.1093/brain/109.4.613

Playford, E. D., Fletcher, N. A., Sawle, G. V., Marsden, C. D. & Brooks, D. J. (1993). Striatal (¹⁸F)dopa uptake in familial idiopathic dystonia. Brain, 116(5), 1191-1199. https://doi.org/10.1093/brain/116.5.1191

Burn, D. J., Rinne, J. O., Quinn, N. P., Lees, A. J., Marsden, C. D. & Brooks, D. J. (1995). Striatal opioid receptor binding in parkinson's disease, striatonigral degeneration and steele-richardson-olszewski syndrome: A [¹¹c]diprenorphine PET study. Brain, 118(4), 951-958. https://doi.org/10.1093/brain/118.4.951

Turjanski, N., Lees, A. J. & Brooks, D. J. (1999). Striatal dopaminergic function in restless legs syndrome: ¹⁸F-dopa and ¹¹C-raclopride PET studies. Neurology, 52(5), 932-937.

Pasquini, J. & Pavese, N. (2021). Striatal dopaminergic denervation and hypomimia in Parkinson's disease. European Journal of Neurology, 28(1), e2-e3. https://doi.org/10.1111/ene.14483

Linnet, J., Mouridsen, K., Peterson, E., Møller, A., Doudet, D. & Gjedde, A. (2012). Striatal dopamine release codes uncertainty in pathological gambling. Psychiatry Research: Neuroimaging, 55.

Turjanski, N., Weeks, R., Dolan, R., Dolan, R., Harding, A. E. & Brooks, D. J. (1995). Striatal D1and D2receptor binding in patients with huntington's disease and other choreas A PET study. Brain, 118(3), 689-696. https://doi.org/10.1093/brain/118.3.689

Weeks, R. A., Piccini, P., Harding, A. E. & Brooks, D. J. (1996). Striatal D1 and D2 dopamine receptor loss in asymptomatic mutation carriers of Huntington's disease. Annals of Neurology, 40(1), 49-54. https://doi.org/10.1002/ana.410400110

Ito, K., Nagano-Saito, A., Kato, T., Arahata, Y., Nakamura, A., Kawasumi, Y., Hatano, K., Abe, Y., Yamada, T., Kachi, T. & Brooks, D. J. (2002). Striatal and extrastriatal dysfunction in Parkinson's disease with dementia: A 6-[¹⁸F]fluoro-L-dopa PET study. Brain, 125(6), 1358-1365. https://doi.org/10.1093/brain/awf134

Scherfler, C., Khan, N. L., Pavese, N., Eunson, L., Graham, E., Lees, A. J., Quinn, N. P., Wood, N. W., Brooks, D. J. & Piccini, P. P. (2004). Striatal and cortical pre- and postsynaptic dopaminergic dysfunction in sporadic parkin-linked parkinsonism. Brain, 127(6), 1332-1342. https://doi.org/10.1093/brain/awh150

Playford, E. D., Fletcher, N. A., Sawle, G. V., Marsden, C. D. & Brooks, D. J. (1993). Striatal [18F]dopa uptake in familial idiopathic dystonia. Brain, 116.

Edison, P., Brooks, D. J., Turkheimer, F. E., Archer, H. A. & Hinz, R. (2009). Strategies for the generation of parametric images of [¹¹C]PIB with plasma input functions considering discriminations and reproducibility. NeuroImage, 48(2), 329-338. https://doi.org/10.1016/j.neuroimage.2009.06.079

Thobois, S., Hotton, G. R., Pinto, S., Wilkinson, L., Limousin-Dowsey, P., Brooks, D. J. & Jahanshahi, M. (2007). STN stimulation alters pallidal-frontal coupling during response selection under competition. Journal of Cerebral Blood Flow and Metabolism, 27(6), 1173-1184. https://doi.org/10.1038/sj.jcbfm.9600425

Blunt, S. B., Brooks, D. J. & Kennard, C. (1994). Steroid‐responsive chorea in childhood following cardiac transplantation. Movement Disorders, 9(1), 112-114. https://doi.org/10.1002/mds.870090123

Boecker, H., Wills, A. J., Ceballos-Baumann, A., Samuel, M., Thomas, D. G. T., Marsden, C. D. & Brooks, D. J. (1997). Stereotactic thalamotomy in tremor-dominant parkinson's disease: An H₂ ¹⁵O PET motor activation study. Annals of Neurology, 41(1), 108-111. https://doi.org/10.1002/ana.410410118

Müller, G. J., Møller, A. & Johansen, F. F. (2001). Stereological cell counts of GABAergic neurons in rat dentate hilus following transient cerebral ischemia. Exp. Brain Research, 141, 380-388.

Ito, K., Morrish, P. K., Rakshi, J. S., Uema, T., Ashburner, J., Bailey, D. L., Friston, K. J. & Brooks, D. J. (1999). Statistical parametric mapping with ¹⁸F-dopa PET shows bilaterally reduced striatal and nigral dopaminergic function in early Parkinson's disease. Journal of Neurology Neurosurgery and Psychiatry, 66(6), 754-758. https://doi.org/10.1136/jnnp.66.6.754

Hammers, A., Chen, C. H., Lemieux, L., Allom, R., Vossos, S., Free, S. L., Myers, R., Brooks, D. J., Duncan, J. S. & Koepp, M. J. (2007). Statistical neuroanatomy of the human inferior frontal gyrus and probabilistic atlas in a standard stereotaxic space. Human Brain Mapping, 28(1), 34-48. https://doi.org/10.1002/hbm.20254

Politis, M., Wu, K., Loane, C., Kiferle, L., Molloy, S., Brooks, D. J. & Piccini, P. (2010). Staging of serotonergic dysfunction in Parkinson's Disease: An in vivo ¹¹C-DASB PET study. Neurobiology of Disease, 40(1), 216-221. https://doi.org/10.1016/j.nbd.2010.05.028

ICICLE-PD Study Group (2017). Stability of mild cognitive impairment in newly diagnosed Parkinson's disease. Journal of Neurology, Neurosurgery & Psychiatry, 88(8), 648-652. https://doi.org/10.1136/jnnp-2016-315099

Lillethorup, T. P., Noer, O., Alstrup, A. K. O., Cristiano Real Gregório, C., Stokholm, K., Thomsen, M., Zaer, H., Orlowski, D., Mikkelsen, T. W., Glud, AN., Nielsen, E. H. T., Schacht, A. C., Winterdahl, M., Brooks, D. J., Sørensen, J. C. H. & Landau, A. (2022). Spontaneous partial recovery of striatal dopaminergic uptake despite nigral cell loss in asymptomatic MPTP-lesioned female minipigs. NeuroToxicology, 91, 166-176. https://doi.org/10.1016/j.neuro.2022.05.006

Migliore, L., Testa, A., Scarpato, R., Pavese, N., Petrozzi, L. & Bonuccelli, U. (1997). Spontaneous and induced aneuploidy in peripheral blood lymphocytes of patients with Alzheimer's disease. Human Genetics, 101(3), 299-305. https://doi.org/10.1007/s004390050632

Hvingelby, V. S., Højholt Terkelsen, M., Johnsen, E. L., Møller, M., Danielsen, E. H., Henriksen, T., Glud, A. N., Tai, Y., Møller Andersen, A. S., Meier, K., Borghammer, P., Moro, E., Sørensen, J. C. H. & Pavese, N. (2022). Spinal cord stimulation therapy for patients with Parkinson's disease and gait problems (STEP-PD): study protocol for an exploratory, double-blind, randomised, placebo-controlled feasibility trial. BMJ Neurology Open, 4(2), Article e000333. https://doi.org/10.1136/bmjno-2022-000333

Rajput, A. H., Boecker, H. & Brooks, D. J. (1996). Specificity of ethanol in essential tremor [4]. Annals of Neurology, 40(6), 950-951.

Nielsen, E. Ø., Warming, T., Mathiesen, C., Jensen, L. H., Møller, A., Gouliaev, A. H., Wätjen, F. & Drejer, J. (1999). SPD 502: A water-soluble and in vivo long-lasting AMPA antagonisk with neuroprotective activity. The Journal of Pharmacology and Experimental Therapeutics, 289, 1492-1501.

Yousif, N., Borisyuk, R., Pavese, N., Nandi, D. & Bain, P. (2012). Spatiotemporal visualization of deep brain stimulation-induced effects in the subthalamic nucleus. The European journal of neuroscience, 36(2), 2252-9. https://doi.org/10.1111/j.1460-9568.2012.08086.x

Krogsbaek, M., Larsen, N. Y., Landau, A. M., Sanchez, C. & Nyengaard, J. R. (2023). Spatial quantification of single cell mRNA and ligand binding of the kappa opioid receptor in the rat hypothalamus. Journal of Chemical Neuroanatomy, 127, Article 102205. https://doi.org/10.1016/j.jchemneu.2022.102205

Dagher, A., Owen, A. M. & Brooks, D. J. (1997). Spatial planning in normal and parkisonian subjects: A PET study. NeuroImage, 5(4 PART II).

Whone, A. L., Watts, R. L., Stoessl, A. J., Davis, M., Reske, S., Nahmias, C., Lang, A. E., Rascol, O., Ribeiro, M. J., Remy, P., Poewe, W. H., Hauser, R. A. & Brooks, D. J. (2003). Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study. Annals of Neurology, 54(1), 93-101. https://doi.org/10.1002/ana.10609

Linnet, J., Rømer Thomsen, K., Møller, A. & Callesen, M. B. (2013). Slot Machine Response Frequency Predicts Pathological Gambling. International Journal of Psychological Studies, 5(1).

Pagano, G., Molloy, S., Bain, P. G., Rabiner, E. A., Chaudhuri, K. R., Pavese, N. & Brooks, D. (2016). Sleep problems and hypothalamic dopamine D3 receptor availability in Parkinson disease. Neurology, 87(23), 2451-2456. https://doi.org/10.1212/WNL.0000000000003396

McGinnity, C. J., Barros, D. A. R., Trigg, W., Brooks, D. J., Hinz, R., Duncan, J. S., Koepp, M. J. & Hammers, A. (2018). Simplifying [ ¹⁸F]GE-179 PET: are both arterial blood sampling and 90-min acquisitions essential? EJNMMI research, 8, Article 46. https://doi.org/10.1186/s13550-018-0396-2

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Henriette Blæsild Vuust