Publications

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Andresen, M. H., Gutiérrez-Jiménez, E. & Matchkov, V. (2025). Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association, 21(S1), Article e097313. https://doi.org/10.1002/alz70855_097313

Mikkelsen, S. H., Christensen, O. B., Postnov, D., Østergaard, L. & Gutiérrez-Jiménez, E. (2025). Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association, 21(S1), Article e105519. https://doi.org/10.1002/alz70855_105519

Gutiérrez-Jiménez, E., Rasmussen, P. M., Mikkelsen, I. K., Kura, S., Fruekilde, S. K., Hansen, B., Bordoni, L., Carlsen, J., Palmfeldt, J., Boas, D. A., Sakadžić, S., Vinogradov, S., Khatib, M. E., Ramos-Cejudo, J., Wied, B., Leduc-Galindo, D., Canepa, E., Mar, A. C., Gamallo-Lana, B. ... Østergaard, L. (2025). Carbonic anhydrase inhibitors prevent presymptomatic capillary flow disturbances in a model of cerebral amyloidosis. Alzheimer's & Dementia, 21(3), Article e70023. https://doi.org/10.1002/alz.70023

Carlsen, J., Fossati, S., Østergaard, L., Gutiérrez-Jiménez, E. & Palmfeldt, J. (2025). Cerebral proteome adaptations to amyloid angiopathy are prevented by carbonic anhydrase inhibitors. Alzheimer's and Dementia, 21(4), Article e70122. https://doi.org/10.1002/alz.70122

Skøtt, M. V., Melnikova, E., Gutiérrez, E., Matchkov, V., Østergaard, L. & Postnov, D. D. (2025). Cortical Microvascular Pulsatility in the Aging Mouse Brain and the Confounding Effects of Anesthesia. Advanced Science. Advance online publication. https://doi.org/10.1002/advs.202519324

Imenez Silva, P. H., Pepin, M., Figurek, A., Gutiérrez-Jiménez, E., Bobot, M., Iervolino, A., Mattace-Raso, F., Hoorn, E. J., Bailey, M. A., Hénaut, L., Nielsen, R., Frische, S., Trepiccione, F., Hafez, G., Altunkaynak, H. O., Endlich, N., Unwin, R., Capasso, G., Pesic, V. ... CONNECT Consortium (2024). Animal models to study cognitive impairment of chronic kidney disease. American journal of physiology. Renal physiology, 326(6), F894-F916. https://doi.org/10.1152/ajprenal.00338.2023

Mikkelsen, S. H., Skøtt, M. V., Gutierrez, E. & Postnov, D. D. (2024). Laser speckle imaging of the hippocampus. Biomedical Optics Express, 15(2), 1268-1277. https://doi.org/10.1364/BOE.507371

Kovbasyuk, Z., Ramos-Cejudo, J., Parekh, A., Bubu, O. M., Ayappa, I. A., Varga, A. W., Chen, M. H., Johnson, A. D., Gutierrez-Jimenez, E., Rapoport, D. M. & Osorio, R. S. (2024). Obstructive Sleep Apnea, Platelet Aggregation, and Cardiovascular Risk. Journal of the American Heart Association, 13(15), e034079. Article e034079. https://doi.org/10.1161/JAHA.123.034079

Farahani, E., Reinert, L. S., Narita, R., Serrero, M. C., Skouboe, M. K., van der Horst, D., Assil, S., Zhang, B., Iversen, M. B., Gutierrez, E., Hazrati, H., Johannsen, M., Olagnier, D., Kunze, R., Denham, M., Mogensen, T. H., Lappe, M. & Paludan, S. R. (2024). The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation. Cell Reports, 43(2), 113792. Article 113792. https://doi.org/10.1016/j.celrep.2024.113792

Jacobs, T., Jacobson, S. R., Fortea, J., Berger, J. S., Vedvyas, A., Marsh, K., He, T., Gutierrez-Jimenez, E., Fillmore, N. R., Gonzalez, M., Figueredo, L., Gaggi, N. L., Plaska, C. R., Pomara, N., Blessing, E., Betensky, R., Rusinek, H., Zetterberg, H., Blennow, K. ... Ramos-Cejudo, J. (2024). The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people. Immunity & ageing , 21(1), Article 32. https://doi.org/10.1186/s12979-024-00435-2

Bordoni, L., Thoren, A. E., Gutiérrez-Jiménez, E., Åbjørsbråten, K. S., Bjørnstad, D. M., Tang, W., Stern, M., Østergaard, L., Nagelhus, E. A., Frische, S., Ottersen, O. P. & Enger, R. (2023). Deletion of aquaporin-4 improves capillary blood flow distribution in brain edema. Glia, 71(11), 2559-2572. https://doi.org/10.1002/glia.24439

Canepa, E., Parodi-Rullan, R., Vazquez-Torres, R., Gamallo-Lana, B., Guzman-Hernandez, R., Lemon, N. L., Angiulli, F., Debure, L., Ilies, M. A., Østergaard, L., Wisniewski, T., Gutiérrez-Jiménez, E., Mar, A. C. & Fossati, S. (2023). FDA-approved carbonic anhydrase inhibitors reduce amyloid β pathology and improve cognition, by ameliorating cerebrovascular health and glial fitness. Alzheimer's & Dementia, 19(11), 5048-5073. https://doi.org/10.1002/alz.13063

Staehr, C., Giblin, J. T., Gutiérrez-Jiménez, E., Guldbrandsen, H. Ø., Tang, J., Sandow, S. L., Boas, D. A. & Matchkov, V. (2023). Neurovascular Uncoupling Is Linked to Microcirculatory Dysfunction in Regions Outside the Ischemic Core Following Ischemic Stroke. Journal of the American Heart Association, 12(11), Article e029527. https://doi.org/10.1161/JAHA.123.029527

Fruekilde, S. K., Bailey, C. J., Lambertsen, K. L., Clausen, B. H., Carlsen, J., Xu, N. L., Drasbek, K. R. & Gutiérrez-Jiménez, E. (2022). Disturbed microcirculation and hyperaemic response in a murine model of systemic inflammation. Journal of Cerebral Blood Flow and Metabolism, 42(12), 2303-2317. https://doi.org/10.1177/0271678X221112278

Mikkelsen, S. H., Wied, B., Dashkovskyi, V., Lindhardt, T. B., Hirschler, L., Warnking, J. M., Barbier, E. L., Postnov, D., Hansen, B. & Gutiérrez-Jiménez, E. (2022). Head holder and cranial window design for sequential magnetic resonance imaging and optical imaging in awake mice. Frontiers in Neuroscience, 16, Article 926828. https://doi.org/10.3389/fnins.2022.926828

Lindhardt, T. B., Gutiérrez-Jiménez, E., Liang, Z. & Hansen, B. (2022). Male and Female C57BL/6 Mice Respond Differently to Awake Magnetic Resonance Imaging Habituation. Frontiers in Neuroscience, 16, Article 853527. https://doi.org/10.3389/fnins.2022.853527

Staehr, C., Giblin, J. T., Gutiérrez-Jiménez, E., Guldbrandsen, H. Ø., Tang, J., Sandow, S. L., Boas, D. A. & Matchkov, V. (2022). Microcirculatory dysfunction associates with neurovascular uncoupling in peri-ischemic brain regions after ischemic stroke. bioRxiv. https://doi.org/10.1101/2022.08.26.505245

Carlsen, J., Gutiérrez-Jiménez, E., Østergaard, L. & Palmfeldt, J. (2022). Proteomes of the TG-SWDI Murine Model of Alzheimer's disease. Poster session presented at Danish Proteomics Society (DAPSOC) Symposium, Odense, Denmark.

Gu, T., Just, J., Stenz, K. T., Yan, Y., Sieljacks, P., Wang, J., Groennebaek, T. S., Jakobsgaard, J. E., Rindom, E., Herskind, J., Gravholt, A., Lassen, T. R., Jørgensen, M., Bæk, R., Gutiérrez-Jiménez, E., Iversen, N. K., Rasmussen, P. M., Nyengaard, J. R., Jørgensen, M. M. ... Drasbek, K. R. (2022). The Role of Plasma Extracellular Vesicles in Remote Ischemic Conditioning and Exercise-Induced Ischemic Tolerance. International Journal of Molecular Sciences , 23(6), Article 3334. https://doi.org/10.3390/ijms23063334

Bordoni, L., Li, B., Kura, S., Boas, D. A., Sakadžić, S., Østergaard, L., Frische, S. & Gutiérrez-Jiménez, E. (2021). Quantification of Capillary Perfusion in an Animal Model of Acute Intracranial Hypertension. Journal of Neurotrauma, 38(4), 446-454. https://doi.org/10.1089/neu.2019.6901

Bordoni, L., Jiménez, E. G., Nielsen, S., Østergaard, L. & Frische, S. (2020). A new experimental mouse model of water intoxication with sustained increased intracranial pressure and mild hyponatremia without side effects of antidiuretics. Experimental animals, 69(1), 92-103. https://doi.org/10.1538/expanim.19-0040

Viggiano, D., Wagner, C. A., Blankestijn, P. J., Bruchfeld, A., Fliser, D., Fouque, D., Frische, S., Gesualdo, L., Gutiérrez, E., Goumenos, D., Hoorn, E. J., Eckardt, K.-U., Knauß, S., König, M., Malyszko, J., Massy, Z., Nitsch, D., Pesce, F., Rychlík, I. ... Capasso, G. (2020). Mild cognitive impairment and kidney disease: clinical aspects. Nephrology Dialysis Transplantation, 35(1), 10-17. https://doi.org/10.1093/ndt/gfz051

Bordoni, L., Gutiérrez-Jiménez, E., Østergaard, L. & Frische, S. (2019). Association between Mild-Hyponatremia with Sustained Increased Intracranial Pressure in a New Animal Model and Assessment of the Effect of dDVAP during Severe Water Intoxication. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(1_supplement), Article 528.1. https://www.fasebj.org/doi/abs/10.1096/fasebj.2019.33.1_supplement.528.1

Gutiérrez-Jiménez, E., Fruekilde, S., Rasmussen, P. M., Mikkelsen, I. K., Iversen, N. K., Bordoni, L., Fossati, S., Ramos-Cejudo, J., Sakadzic, S. & Østergaard, L. (2019). The effect of carbonic anhydrase inhibitors in brain microcirculation of the Tg-SwDI model of Alzheimer's disease. Journal of Cerebral Blood Flow and Metabolism, 39(1_suppl), Article PB02-O02. https://doi.org/10.1177/0271678X19851020

Gutierrez-Jimenez, E., Angleys, H., Rasmussen, P. M., West, M. J., Catalini, L., Iversen, N. K., Jensen, M. S., Frische, S. & Ostergaard, L. (2018). Disturbances in the control of capillary flow in an aged APP(swe)/PS1 Delta E9 model of Alzheimer's disease. Neurobiology of Aging, 62, 82-94. https://doi.org/10.1016/j.neurobiolaging.2017.10.006

Gutiérrez-Jiménez, E., Angleys, H., Rasmussen, P. M., Mikkelsen, I. K., Mouridsen, K. & Østergaard, L. (2018). The effects of hypercapnia on cortical capillary transit time heterogeneity (CTH) in anesthetized mice. Journal of Cerebral Blood Flow and Metabolism, 38(2), 290-303. Article 271678X17692598. https://doi.org/10.1177/0271678X17692598

Dudele, A., Gutierrez, E., Iversen, N. K., Frische, S., Staehelin-Jensen, T. & Østergaard, L. (2017). Capillary dysfunction in the development of diabetic peripheral neuropathy in animal models. 276-276. Abstract from 2017 PNS (Peripheral Nerve Society) Annual Meeting , Barcelona, Spain. https://doi.org/10.1111/jns.12225

Bordoni, L., Jimenez, E. G., Ostergaard, L. & Frische, S. (2017). Role of Renal Compensation and dDAVP in a Mouse Model of Hyponatremia and Brain Edema induced by Water Intoxication.

Gutiérrez-Jiménez, E., Cai, C., Mikkelsen, I. K., Rasmussen, P. M., Angleys, H., Merrild, M., Mouridsen, K., Jespersen, S. N., Lee, J., Iversen, N. K., Sakadzic, S. & Østergaard, L. (2016). Effect of electrical forepaw stimulation on capillary transit-time heterogeneity (CTH). Journal of Cerebral Blood Flow and Metabolism, 36(12), 2072-2086. https://doi.org/10.1177/0271678X16631560

Østergaard, L., Jespersen, S. N., Engedal, T. S., Jiménez, E. G., Ashkanian, M., Hansen, M. B., Eskildsen, S. & Mouridsen, K. (2015). Capillary dysfunction: Its detection and causative role in dementias and stroke. Current Neurology and Neuroscience Reports, 15(6), 37. https://doi.org/10.1007/s11910-015-0557-x

Østergaard, L., Aamand, R., Gutiérrez Jiménez, E., Ho, Y. C. L., Blicher, J., Madsen, S. M., Nagenthiraja, K., Dalby, R. B., Drasbek, K. R., Møller, A., Brændgaard, H., Mouridsen, K., Jespersen, S. N., Jensen, M. S. & West, M. J. (2013). The capillary dysfunction hypothesis of Alzheimer's disease. Neurobiology of Aging, 34(4), 1018-31. https://doi.org/10.1016/j.neurobiolaging.2012.09.011

Østergaard, L., Aamand, R., Karabegovic, S., Tietze, A., Blicher, J. U., Mikkelsen, I. K., Iversen, N. K., Secher, N., Engedal, T. S., Anzabi, M., Jimenez, E. G., Cai, C., Koch, K. U., Næss-Schmidt, E. T., Obel, A., Juul, N., Rasmussen, M. & Sørensen, J. C. H. (2013). The role of the microcirculation in delayed cerebral ischemia and chronic degenerative changes after subarachnoid hemorrhage. Journal of Cerebral Blood Flow and Metabolism, 33(12), 1825-37. https://doi.org/10.1038/jcbfm.2013.173

Martínez, H. R., Molina-Lopez, J. F., González-Garza, M. T., Moreno-Cuevas, J. E., Caro-Osorio, E., Gil-Valadez, A., Gutierrez-Jimenez, E., Zazueta-Fierro, O. E., Meza, J. A., Couret-Alcaraz, P. & Hernandez-Torre, M. (2012). Stem cell transplantation in amyotrophic lateral sclerosis patients: methodological approach, safety, and feasibility. Cell Transplantation, 21(9), 1899-907. https://doi.org/10.3727/096368911X582769

Martinez, H. R., Gonzalez-Garza, M. T., Moreno-Cuevas, J. E., Caro, E., Gutierrez-Jimenez, E. & Segura, J. J. (2009). Stem-cell transplantation into the frontal motor cortex in amyotrophic lateral sclerosis patients. Cytotherapy, 11(1), 26-34. https://doi.org/10.1080/14653240802644651

Martínez Héctor, R., Caro-Osorio, E., Gutiérrez-Jiménez, E., Moreno-Cuevas, J. & González-Garza, M. T. (2008). Amiotrofia monomiélica. Revista Mexicana de Neurociencia, 9(1), 70-73.

Revised 09.01.2026

Henriette Blæsild Vuust