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Exploring vascular contributions to cognitive impairment and dementia (ENIGMA): protocol for a prospective observational study.
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Integration of long-read sequencing, DNA methylation and gene expression reveals heterogeneity in Y chromosome segment lengths in phenotypic males with 46,XX testicular disorder/difference of sex development.
Biology of Sex Differences,
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Hasselholt, S., Cömert, C., Just, J., Bross, P., Nyengaard, J. R., Hansen, B. & Østergaard, L. (2024).
Microvessel and mitochondria changes in a mouse model of Alzheimer’s disease.
BIO Web of Conferences,
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Mild liver dysfunction in Klinefelter syndrome is associated with abdominal obesity and elevated lipids but not testosterone treatment.
Journal of Endocrinological Investigation,
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Obstructive Sleep Apnea, Platelet Aggregation, and Cardiovascular Risk.
Journal of the American Heart Association,
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Testosterone replacement therapy in Klinefelter syndrome - follow-up study associating hemostasis and RNA expression.
The Journal of clinical endocrinology and metabolism,
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The effect of remote ischemic conditioning on clinical endpoints and treatment adherence in patients with acute ischemic stroke.
Conditioning Medicine,
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The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation.
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The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people.
Immunity & ageing ,
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A Prospective Study of Lipids in Adult Women With Turner Syndrome.
Journal of the Endocrine Society,
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Deletion of aquaporin-4 improves capillary blood flow distribution in brain edema.
Glia,
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Dosage of the pseudoautosomal gene SLC25A6 is implicated in QTc interval duration.
Scientific Reports,
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FDA-approved carbonic anhydrase inhibitors reduce amyloid β pathology and improve cognition, by ameliorating cerebrovascular health and glial fitness.
Alzheimer's & Dementia,
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Neurovascular Uncoupling Is Linked to Microcirculatory Dysfunction in Regions Outside the Ischemic Core Following Ischemic Stroke.
Journal of the American Heart Association,
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T-cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapy.
Journal of Extracellular Vesicles,
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The Changing Face of Turner Syndrome.
Endocrine Reviews,
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The multi-omic landscape of sex chromosome abnormalities: current status and future directions.
Endocrine Connections,
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The testicular microvasculature in Klinefelter syndrome is immature with compromised integrity and characterized by excessive inflammatory cross-talk.
Human reproduction (Oxford, England),
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X chromosome dosage and the genetic impact across human tissues.
Genome Medicine,
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Disturbed microcirculation and hyperaemic response in a murine model of systemic inflammation.
Journal of Cerebral Blood Flow and Metabolism,
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Epigenetic and transcriptomic alterations in offspring born to women with type 1 diabetes (the EPICOM study).
BMC Medicine,
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Head holder and cranial window design for sequential magnetic resonance imaging and optical imaging in awake mice.
Frontiers in Neuroscience,
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Improved Fluorescent Proteins for Dual-Colour Post-Embedding CLEM.
Cells,
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, Skakkebæk, A. & Gravholt, C. H. (2022).
Sex chromosome aneuploidies give rise to changes in the circular RNA profile: A circular transcriptome-wide study of Turner and Klinefelter syndrome across different tissues.
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The Role of Plasma Extracellular Vesicles in Remote Ischemic Conditioning and Exercise-Induced Ischemic Tolerance.
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Women With Turner Syndrome Are Both Estrogen and Androgen Deficient: The Impact of Hormone Replacement Therapy.
The Journal of clinical endocrinology and metabolism,
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Cardioprotection by remote ischemic conditioning is transferable by plasma and mediated by extracellular vesicles.
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Cyclic hypoxia conditioning alters the content of myoblast-derived extracellular vesicles and enhances their cell-protective functions.
Biomedicines,
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Human skeletal muscle CD90+ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetic patients.
Cell Metabolism,
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, Pedersen, S. B., Petersen, K. K., Bjerre, M., Farup, J. & Jessen, N. (2021).
Isolation and characterization of muscle stem cells, fibro-adipogenic progenitors and macrophages from human skeletal muscle biopsies.
American journal of physiology. Cell physiology,
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Bordoni, L., Li, B., Kura, S.
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Quantification of Capillary Perfusion in an Animal Model of Acute Intracranial Hypertension.
Journal of Neurotrauma,
38(4), 446-454.
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Jørgensen, M. L., Müller, C. A., Nøddesbo, M. S. K., Nadzieja, M., Zhang, Z., Su, Y., Just, J., Spindler, K.-L. G. & Chen, M. (2020).
A Melt-electrowritten Filter for Capture and Culture of Circulating Colon Cancer Cells.
Materials Today Bio,
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A new experimental mouse model of water intoxication with sustained increased intracranial pressure and mild hyponatremia without side effects of antidiuretics.
Experimental animals,
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https://doi.org/10.1538/expanim.19-0040
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Blood flow-restricted resistance exercise alters the surface profile, miRNA cargo and functional impact of circulating extracellular vesicles.
Scientific Reports,
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Viggiano, D., Wagner, C. A., Blankestijn, P. J., Bruchfeld, A., Fliser, D., Fouque, D.
, Frische, S., Gesualdo, L.
, Gutiérrez, E., Goumenos, D., Hoorn, E. J., Eckardt, K.-U., Knauß, S., König, M., Malyszko, J., Massy, Z., Nitsch, D., Pesce, F., Rychlík, I. ... Capasso, G. (2020).
Mild cognitive impairment and kidney disease: clinical aspects.
Nephrology Dialysis Transplantation,
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CIRCULATING EXTRACELLULAR VESICLES RELEASED AFTER ISCHEMIC EXERCISE EXHIBIT AN ALTERED MIRNA PROFILE AND INDUCE PROLIFERATION OF SKELETAL MUSCLE PRECURSOR CELLS. Abstract from Danish Diabetes Academy: Non-coding RNA´s in Metabolic Disease, Copenhagen, Denmark.
Just, J., Munk Ipsen, P., Kruhøffer, M.
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Human Mast Cell Sensitization with IgE Increases miRNA-210 Expression.
International Archives of Allergy and Immunology,
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& Østergaard, L. (2019).
The effect of carbonic anhydrase inhibitors in brain microcirculation of the Tg-SwDI model of Alzheimer's disease.
Journal of Cerebral Blood Flow and Metabolism,
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Gutierrez-Jimenez, E., Angleys, H., Rasmussen, P. M., West, M. J., Catalini, L.
, Iversen, N. K., Jensen, M. S., Frische, S. & Ostergaard, L. (2018).
Disturbances in the control of capillary flow in an aged APP(swe)/PS1 Delta E9 model of Alzheimer's disease.
Neurobiology of Aging,
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Bay, V., Kjølby, B. F., Iversen, N. K., Mikkelsen, I. K., Ardalan, M., Nyengaard, J. R., Jespersen, S. N., Drasbek, K. R., Østergaard, L. & Hansen, B. (2018).
Stroke infarct volume estimation in fixed tissue: Comparison of diffusion kurtosis imaging to diffusion weighted imaging and histology in a rodent MCAO model.
PLOS ONE,
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Gutiérrez-Jiménez, E., Angleys, H., Rasmussen, P. M., Mikkelsen, I. K., Mouridsen, K. & Østergaard, L. (2018).
The effects of hypercapnia on cortical capillary transit time heterogeneity (CTH) in anesthetized mice.
Journal of Cerebral Blood Flow and Metabolism,
38(2), 290-303. Article 271678X17692598.
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Lykkemark, S., Mandrup, O. A., Jensen, M. B., Just, J. & Kristensen, P. (2017).
A novel excision selection method for isolation of antibodies binding antigens expressed specifically by rare cells in tissue sections.
Nucleic Acids Research,
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Capillary dysfunction in the development of diabetic peripheral neuropathy in animal models. 276-276. Abstract from 2017 PNS (Peripheral Nerve Society) Annual Meeting , Barcelona, Spain.
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Bertelsen, F., Møller, A., Folloni, D.
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Increased GABAA receptor binding in amygdala after prenatal administration of valproic acid to rats.
Acta Neuropsychiatrica,
29(5), 309-3014.
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Just, J., Lykkemark, S., Nielsen, C. H., Roshenas, A. R.
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Pericyte modulation by a functional antibody obtained by a novel single cell selection strategy.
Microcirculation,
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Effect of electrical forepaw stimulation on capillary transit-time heterogeneity (CTH).
Journal of Cerebral Blood Flow and Metabolism,
36(12), 2072-2086.
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Capillary dysfunction: Its detection and causative role in dementias and stroke.
Current Neurology and Neuroscience Reports,
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Sørensen, E. M.
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Hyperactivity and lack of social discrimination in the adolescent Fmr1 knockout mouse.
Behavioural Pharmacology,
26(8 Spec No), 733-40.
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Just, J., Jung, T.
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Identification of an unstable 4-hydroxynoneal modification on the 20S proteasome subunit α7 by recombinant antibody technology.
Free Radical Biology & Medicine,
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The effects of capillary dysfunction on oxygen and glucose extraction in diabetic neuropathy.
Diabetologia,
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Østergaard, L., Terkelsen, A. J., Finnerup, N. B., Knudsen, L., Drasbek, K. R., Jespersen, S. N., Svensson, P., Sørensen, J. C. H. & Jensen, T. S. (2014).
Capillary dysfunction and impaired tissue oxygenation in complex regional pain syndrome: A hypothesis.
Pain,
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Østergaard, L., Engedal, T. S., Aamand, R., Mikkelsen, R., Iversen, N. K., Anzabi, M., Næss-Schmidt, E., Drasbek, K. R., Bay, V., Blicher, J., Tietze, A., Mikkelsen, I. K., Hansen, B., Jespersen, S. N., Juul, N., Sørensen, J. CH. & Rasmussen, M. (2014).
Capillary transit time heterogeneity and flow-metabolism coupling after traumatic brain injury.
Journal of Cerebral Blood Flow and Metabolism,
34(10), 1585-1598.
https://doi.org/10.1038/jcbfm.2014.131
Jørgensen, M. L., Friis, N. A., Just, J., Madsen, P., Petersen, S. V. & Kristensen, P. (2014).
Expression of single-chain variable fragments fused with the Fc-region of rabbit IgG in Leishmania tarentolae.
Microbial Cell Factories,
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Mandrup, O. A., Friis, N. A., Lykkemark, S., Just, J. & Kristensen, P. (2013).
A novel heavy domain antibody library with functionally optimized complementarity determining regions.
PLOS ONE,
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Hjernen- fra celle til samfund. Systime Academic.
Østergaard, L., Aamand, R., Gutiérrez Jiménez, E., Ho, Y. C. L., Blicher, J., Madsen, S. M., Nagenthiraja, K., Dalby, R. B., Drasbek, K. R., Møller, A., Brændgaard, H., Mouridsen, K., Jespersen, S. N., Jensen, M. S. & West, M. J. (2013).
The capillary dysfunction hypothesis of Alzheimer's disease.
Neurobiology of Aging,
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The relationship between tumor blood flow, angiogenesis, tumor hypoxia, and aerobic glycolysis.
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The role of the microcirculation in delayed cerebral ischemia and chronic degenerative changes after subarachnoid hemorrhage.
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Severe chronic allergic (and related) diseases: a uniform approach--a MeDALL--GA2LEN--ARIA position paper.
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Stem cell transplantation in amyotrophic lateral sclerosis patients: methodological approach, safety, and feasibility.
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The activity of the proteasome during the lifespan of Caenorhabditis elegans and its relation to longevity. Poster session presented at
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Horizontal transfer of the immunoglobulin A1 protease gene (iga) from Streptococcus to Gemella haemolysans.
Microbiology,
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